Ahmed T, Bosl G J, Hajdu S I
Cancer. 1985 Aug 15;56(4):860-3. doi: 10.1002/1097-0142(19850815)56:4<860::aid-cncr2820560426>3.0.co;2-3.
Pathology reports of over 580 male patients with germ cell tumors treated between 1972 and 1982 were screened for teratomas in which malignant transformation was apparent. The diagnosis was established in 17 cases. The median age was 28 years (range, 14-52). For patients with disease limited to the testis, the median survival has not been reached, with all five patients surviving disease-free at 22+ to 120+ months. Among the 12 patients with metastatic disease, the median survival was 30.5 months (range, 12-69). All 12 patients were treated with cisplatin-containing regimens. Six had complete responses either to chemotherapy alone or to chemotherapy plus resection of residual disease. Four of the six complete responders relapsed, and three died of progressive disease. One patient with sarcomatous differentiation was treated with a doxorubicin-based regimen and had a partial remission, which lasted 8 months. Teratoma with malignant transformation, when found in metastatic sites, appeared to be a poor prognostic pathologic variant in male patients with germ cell tumors.
对1972年至1982年间接受治疗的580多名患有生殖细胞肿瘤的男性患者的病理报告进行筛查，以寻找明显发生恶性转化的畸胎瘤。确诊17例。中位年龄为28岁（范围14 - 52岁）。对于疾病局限于睾丸的患者，中位生存期尚未达到，5例患者均无病存活22 +至120 +个月。在12例有转移疾病的患者中，中位生存期为30.5个月（范围12 - 69个月）。所有12例患者均接受含顺铂方案治疗。6例患者对单纯化疗或化疗加残留病灶切除有完全缓解。6例完全缓解者中有4例复发，3例死于疾病进展。1例有肉瘤样分化的患者接受了以阿霉素为基础方案的治疗，有部分缓解，持续8个月。在转移部位发现的恶性转化畸胎瘤，在患有生殖细胞肿瘤的男性患者中似乎是一种预后不良的病理变体。
