Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, Qingdao, China.
J Epidemiol Community Health. 2018 Nov;72(11):1064-1070. doi: 10.1136/jech-2018-210820. Epub 2018 Jun 15.
The association between environmental tobacco smoke (ETS) exposure and habitual snoring (HS) risk in children remains controversial. Therefore, a meta-analysis was carried out to evaluate and compare the effect of ETS by different family members and prenatal smoke exposure on the risk of HS in children.
Relevant studies published in English were identified by a search of PubMed, Embase and Web of Science up to December 2017. Random effect model and fixed effect model were used to pool the findings. Restricted cubic splines were used to assess the dose-response relationship.
A total of 24 studies with 87 829 participants were included in the present meta-analysis. When comparing ETS exposed with non-ETS exposed, the pooled OR of HS were 1.46 (95% CI, 1.29 to 1.65) for household smoking exposure, 1.45 (95% CI, 1.27 to 1.65) for paternal smoking exposure, 1.87 (95% CI, 1.56 to 2.23) for maternal smoking exposure and 1.95 (95% CI, 1.63 to 2.34) for prenatal tobacco smoke exposure. For dose-response analysis, evidence of a linear association was found between household smoking exposure and HS, and the risk of HS increased by 2.1% (OR=1.02, 95% CI, 1.00 to 1.04, p=0.022) for every 1 cigarette/day increment of smoking by people living with children.
This meta-analysis of observational studies indicates that exposure to ETS, in particularly prenatal tobacco smoke exposure and maternal smoking, is associated with an increased risk of HS.
环境烟草烟雾（ETS）暴露与儿童习惯性打鼾（HS）风险之间的关联仍存在争议。因此，进行了一项荟萃分析，以评估和比较不同家庭成员的 ETS 暴露和产前吸烟暴露对儿童 HS 风险的影响。
通过检索 PubMed、Embase 和 Web of Science，截至 2017 年 12 月，确定了发表在英文期刊上的相关研究。使用随机效应模型和固定效应模型汇总研究结果。限制性立方样条用于评估剂量-反应关系。
本荟萃分析共纳入 24 项研究，共 87829 名参与者。与非 ETS 暴露相比，家庭吸烟暴露、父亲吸烟暴露、母亲吸烟暴露和产前烟草烟雾暴露的 HS 比值比（OR）分别为 1.46（95%可信区间，1.29 至 1.65）、1.45（95%可信区间，1.27 至 1.65）、1.87（95%可信区间，1.56 至 2.23）和 1.95（95%可信区间，1.63 至 2.34）。对于剂量-反应分析，发现家庭吸烟暴露与 HS 之间存在线性关联，每增加 1 支/天的吸烟量，HS 的风险增加 2.1%（OR=1.02，95%可信区间，1.00 至 1.04，p=0.022）。
本项观察性研究的荟萃分析表明，ETS 暴露，特别是产前烟草烟雾暴露和母亲吸烟，与 HS 风险增加相关。
