Ishihara T, Waseda N, Ikekubo K, Kuroda K, Akamizu T, Mori T
Endocrinol Jpn. 1985 Feb;32(1):189-94. doi: 10.1507/endocrj1954.32.189.
A 26-yr-old female with primary hypothyroidism due to potent blocking type thyrotropin binding inhibitor immunoglobulins (TBII) was advised of the high risk of bearing a baby with neonatal transient hypothyroidism. This prediction proved valid and her baby was found to be hypothyroid with a potent TBII. By expressing the baby's TBII as the absolute concentration, we found an almost linear regression of TBII and the half-life was calculated as 18.0 days. The TBII became undetectable by the 6th month and thyroid medication was stopped, however the baby remained euthyroid with subsequent normal physical and mental development.
一名26岁的女性，因存在强效阻断型促甲状腺素结合抑制性免疫球蛋白（TBII）而患有原发性甲状腺功能减退症，她被告知怀有新生儿暂时性甲状腺功能减退症患儿的风险很高。这一预测被证明是正确的，她的婴儿被发现患有甲状腺功能减退症且存在强效TBII。通过将婴儿的TBII表示为绝对浓度，我们发现TBII几乎呈线性消退，计算出半衰期为18.0天。到第6个月时TBII检测不到，甲状腺药物停用，但婴儿仍维持甲状腺功能正常，随后身体和智力发育正常。
