Arisaka O, Arisaka M, Nakayama Y, Shimura N, Obinata K, Ino T, Niijima S, Akiyama T, Yabuta K, Arikawa K
Am J Dis Child. 1986 Oct;140(10):998-1000. doi: 10.1001/archpedi.1986.02140240044023.
Two patients with hypothyroidism had detectable serum levels of thyrotropin binding inhibitor immunoglobulin (TBII). Patient 1 was a newborn infant who had transient neonatal hypothyroidism due to transfer of TBII from the mother with nongoitrous autoimmune thyroiditis. Patient 2 was an 8-year-old girl with Down's syndrome who presented with signs of myxedema and central precocious puberty. She had no goiter, and the recognition of thyroid disease was delayed; the histological diagnosis of chronic lymphocytic thyroiditis was established by aspiration biopsy, and TBII had strong thyroid adenyl cyclase-inhibiting activity in vitro. It appears that TBII may be pathogenetically important for occurrence of neonatal hypothyroidism and nongoitrous autoimmune thyroiditis without goiter.
两名甲状腺功能减退患者的血清中可检测到促甲状腺激素结合抑制性免疫球蛋白（TBII）。患者1是一名新生儿，因患有非甲状腺肿性自身免疫性甲状腺炎的母亲传递TBII而患有短暂性新生儿甲状腺功能减退。患者2是一名8岁患有唐氏综合征的女孩，表现出黏液性水肿和中枢性性早熟的症状。她没有甲状腺肿，甲状腺疾病的诊断延迟；通过穿刺活检确诊为慢性淋巴细胞性甲状腺炎，且TBII在体外具有很强的甲状腺腺苷酸环化酶抑制活性。看来，TBII可能在新生儿甲状腺功能减退和无甲状腺肿的非甲状腺肿性自身免疫性甲状腺炎的发病机制中具有重要作用。
