Harvard Radiation Oncology Program, Boston, MA 02114, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Surgical Oncology, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
J Control Release. 2018 Aug 28;284:144-151. doi: 10.1016/j.jconrel.2018.06.020. Epub 2018 Jun 15.
Despite major advancements in cancer treatments, there are still many limitations to therapy including off-target effects, drug resistance, and control of cancer-related symptoms. There are opportunities for local drug delivery devices to intervene at various stages of cancer to provide curative and palliative benefit. Iontophoretic devices that deliver drugs locally to a region of interest have been adapted for the treatment of cancer. These devices have shown promise in pre-clinical and clinical studies for retinoblastoma, skin, bladder, and pancreatic cancers. Herein, we review iontophoretic devices used in the management of cancer.
尽管癌症治疗取得了重大进展，但仍存在许多治疗局限性，包括脱靶效应、耐药性和对癌症相关症状的控制。局部药物递送装置有机会在癌症的各个阶段进行干预，以提供治愈和姑息性的益处。已经开发出将药物局部递送至感兴趣区域的离子电渗设备来治疗癌症。这些设备在视网膜母细胞瘤、皮肤、膀胱和胰腺癌的临床前和临床研究中显示出了希望。在此，我们回顾了用于癌症管理的离子电渗设备。
