Department of Mechanical Engineering, University of Connecticut, Storrs, USA.
Department of Biomedical Engineering, University of Connecticut, Storrs, USA.
Drug Deliv Transl Res. 2022 Nov;12(11):2613-2633. doi: 10.1007/s13346-022-01138-1. Epub 2022 May 10.
Gene therapy is a critical constituent of treatment approaches for genetic diseases and has gained tremendous attention. Treating and preventing diseases at the genetic level using genetic materials such as DNA or RNAs could be a new avenue in medicine. However, delivering genes is always a challenge as these molecules are sensitive to various enzymes inside the body, often produce systemic toxicity, and suffer from off-targeting problems. In this regard, transdermal delivery has emerged as an appealing approach to enable a high efficiency and low toxicity of genetic medicines. This review systematically summarizes outstanding transdermal gene delivery methods for applications in skin cancer treatment, vaccination, wound healing, and other therapies.
基因治疗是治疗遗传疾病的重要方法，受到了广泛关注。利用 DNA 或 RNA 等遗传物质在基因水平上治疗和预防疾病可能是医学的一个新途径。然而，由于这些分子对体内的各种酶敏感，经常产生全身毒性，并存在脱靶问题，因此输送基因一直是一个挑战。在这方面，经皮给药作为一种有吸引力的方法，能够实现基因药物的高效和低毒性。本文系统地综述了用于皮肤癌治疗、疫苗接种、伤口愈合和其他治疗的优秀经皮基因传递方法。
