加工红肉摄入量与 COPD 风险：前瞻性队列研究的系统评价和剂量反应荟萃分析。
Processed red meat intake and risk of COPD: A systematic review and dose-response meta-analysis of prospective cohort studies.
机构信息
Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Clin Nutr. 2019 Jun;38(3):1109-1116. doi: 10.1016/j.clnu.2018.05.020. Epub 2018 Jun 1.
BACKGROUND & AIMS: No earlier study has summarized findings from previous publications on processed red meat intake and risk of Chronic Obstructive Pulmonary Disease (COPD). This systematic review and meta-analysis was conducted to examine the association between processed red meat intake and COPD risk.
METHODS
We searched in PubMed/Medline, ISI Web of Knowledge, Scopus, EMBASE and Google Scholar up to April 2018 to identify relevant studies. Prospective cohort studies that considered processed red meat as the exposure variable and COPD as the main outcome variable or as one of the outcomes were included in the systematic review. Publications in which hazard ratios (HRs) were reported as effect size were included in the meta-analysis. Finally, five cohort studies were considered in this systematic review and meta-analysis.
RESULTS
In total, 289,952 participants, including 8338 subjects with COPD, aged ≥27 years were included in the meta-analysis. These studies were from Sweden and the US. Linear dose response meta-analysis revealed that each 50 gr/week increase in processed red meat intake was associated with 8% higher risk of COPD (HR: 1.08; 95% CI: 1.03, 1.13). There was an evidence of non-linear association between processed red meat intake and risk of COPD (P < 0.001).
CONCLUSIONS
In this systematic review and meta-analysis, we found a significant positive association between processed red meat intake and risk of COPD.
PROSPERO REGISTRATION NUMBER
CRD42017077971.
背景与目的
此前尚无研究对以往关于加工红肉摄入量与慢性阻塞性肺疾病（COPD）风险的研究结果进行总结。本系统评价和荟萃分析旨在研究加工红肉摄入量与 COPD 风险之间的相关性。
方法
我们在 PubMed/Medline、ISI Web of Knowledge、Scopus、EMBASE 和 Google Scholar 上检索了截至 2018 年 4 月的相关研究。将考虑加工红肉为暴露变量、COPD 为主要结局变量或结局之一的前瞻性队列研究纳入系统评价。将报告危害比（HRs）作为效应量的出版物纳入荟萃分析。最终，本系统评价和荟萃分析共纳入 5 项队列研究。
结果
共有 289952 名年龄≥27 岁的参与者纳入荟萃分析，包括 8338 名 COPD 患者。这些研究来自瑞典和美国。线性剂量反应荟萃分析显示，加工红肉摄入量每增加 50 克/周，COPD 风险增加 8%（HR：1.08；95%CI：1.03，1.13）。加工红肉摄入量与 COPD 风险之间存在非线性关联（P<0.001）。
结论
在本系统评价和荟萃分析中，我们发现加工红肉摄入量与 COPD 风险之间存在显著的正相关关系。
PROSPERO 注册号：CRD42017077971。
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