Hallam S, Rickard F, Reeves N, Messenger D, Shabbir J
University Hospitals Bristol NHS Foundation Trust , UK.
Ann R Coll Surg Engl. 2018 Sep;100(7):570-579. doi: 10.1308/rcsann.2018.0102. Epub 2018 Jun 18.
Introduction Enhanced recovery after surgery (ERAS) is associated with reduced length of stay (LOS) and improved outcomes in colorectal surgery. It is unclear whether ERAS can be safely implemented in elderly patients undergoing complex colorectal resections. The aim of this study was to evaluate the feasibility of ERAS in patients of all ages undergoing colorectal surgery. Methods A prospective database of a consecutive series of patients undergoing colorectal resections with ERAS between August 2012 and December 2014 was evaluated. Patients were divided into four age groups. Outcomes studied were compliance with ERAS elements, LOS, morbidity and mortality. Results Of the 294 patients in the study cohort, 79 were <60 years, 81 were 60-69 years, 86 were 70-79 years and 48 were ≥80 years of age. There was no significant difference between age groups in compliance with ERAS elements. Age was not predictive of delayed discharge (LOS >6 days) or morbidity. Factors that were predictive of delayed discharge on multivariate analysis were open surgery (odds ratio [OR]: 2.23, p=0.003), conversion to open surgery (OR: 3.23, p=0.017), stoma formation (OR: 2.10, p=0.019) and chronic obstructive pulmonary disease (OR: 4.12, p=0.038). Factors predictive of morbidity on multivariate analysis comprised conversion to open surgery (OR: 7.72, p=0.004), high creatinine (OR: 1.03 per unit increase in creatinine, p=0.008) and stoma education (OR: 0.31, p=0.030). Conclusions ERAS can be successfully implemented in older patients. There was equal compliance with the ERAS programme across the four age groups and no significant effect of age on LOS or morbidity.
引言 手术后加速康复(ERAS)与结直肠手术中住院时间缩短及预后改善相关。目前尚不清楚ERAS能否在接受复杂结直肠切除术的老年患者中安全实施。本研究的目的是评估ERAS在所有年龄段接受结直肠手术患者中的可行性。方法 对2012年8月至2014年12月期间接受ERAS结直肠切除术的连续系列患者的前瞻性数据库进行评估。患者分为四个年龄组。研究的结局指标包括对ERAS要素的依从性、住院时间、发病率和死亡率。结果 在研究队列的294例患者中,79例年龄<60岁,81例年龄在60 - 69岁之间,86例年龄在70 - 79岁之间,48例年龄≥80岁。各年龄组在对ERAS要素的依从性方面无显著差异。年龄不能预测延迟出院(住院时间>6天)或发病率。多因素分析中预测延迟出院的因素包括开放手术(比值比[OR]:2.23,p = 0.003)、转为开放手术(OR:3.23,p = 0.017)、造口形成(OR:2.10,p = 0.019)和慢性阻塞性肺疾病(OR:4.12,p = 0.038)。多因素分析中预测发病率的因素包括转为开放手术(OR:7.72,p = 0.004)、高肌酐水平(肌酐每增加一个单位,OR:1.03,p = 0.008)和造口教育(OR:0.31,p = 0.030)。结论 ERAS可在老年患者中成功实施。四个年龄组对ERAS方案的依从性相同,年龄对住院时间或发病率无显著影响。