Fujiyama S, Akahoshi M, Sagara K, Sato T, Tsurusaki R
Gastroenterol Jpn. 1985 Feb;20(1):6-13. doi: 10.1007/BF02774668.
An epidemic of hepatitis A occurred around Hondo City, Kumamoto Prefecture in Japan during the first six months of 1982. Clinical, immunological and epidemiological studies were carried out in 225 cases. Cases were distributed over a relatively wide area, and in small numbers of young children and school children. More than half of the patients were in their twenties or thirties. The clinical course was generally favorable with rapid resolution. No episode lasted more than six months. There was only one fatality in a cure which was a carrier of HBs antigen with liver cirrhosis. Titers of IgM anti-HAV measured by radioimmunoassay (RIA) or enzyme immunoassay (EIA) reached a peak during the second week after onset, followed by a gradual decrease. Conversion to negative results was never experienced within two months. We found a good correlation between RIA and EIA in terms of detecting IgM anti-HAV. The route of infection was thought to be fecal-oral in nature, with ingestion of raw oysters the major etiologic factor.
1982年上半年，日本熊本县本渡市周边地区发生了甲型肝炎疫情。对225例病例进行了临床、免疫学和流行病学研究。病例分布在相对较广的区域，少数为幼儿和学童。超过一半的患者年龄在二十多岁或三十多岁。临床病程一般良好，恢复迅速。没有病程超过六个月的病例。在一名治愈的患者中仅有一例死亡，该患者是一名携带乙肝表面抗原的肝硬化患者。通过放射免疫测定法（RIA）或酶免疫测定法（EIA）检测的IgM抗甲型肝炎病毒抗体效价在发病后第二周达到峰值，随后逐渐下降。在两个月内从未出现过转为阴性结果的情况。我们发现在检测IgM抗甲型肝炎病毒抗体方面，RIA和EIA之间具有良好的相关性。感染途径被认为本质上是粪口途径，食用生牡蛎是主要病因。
