The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, 430072, P.R China.
Henan Key Laboratory of Ecological Security for Water Source Region of Mid-line of South-to-North Diversion Project, Collaborative Innovation Center of Water Security for Water Source Region of Mid-line of South-to-North Diversion Project of Henan Province, Nanyang Normal University.
Int J Biol Sci. 2018 May 21;14(7):791-798. doi: 10.7150/ijbs.23744. eCollection 2018.
The circadian system maintains the main aspects of physiological and behavioral processes. Both circadian rhythm and sleep impact an organism's health through interaction with environmental factors. Variations in external factors influence the functionality of clock genes and disrupt 24-hour rhythmic cycle. The disrupted circadian rhythm and disregulated sleep affect an organism's health, thereby causing several disorders including cancer, depression and cardiac disorders. Considering the role of clock genes and environmental factors, extensive investigation is required focusing on pathways involved in development of life-threatening disorders. This review identifies the major risks and associated factors related with disruption in circadian system and sleep.
昼夜节律系统维持着生理和行为过程的主要方面。昼夜节律和睡眠都通过与环境因素的相互作用影响生物体的健康。外部因素的变化会影响生物钟基因的功能，破坏 24 小时的节律周期。昼夜节律紊乱和睡眠失调会影响生物体的健康，从而导致多种疾病，包括癌症、抑郁症和心脏疾病。鉴于时钟基因和环境因素的作用，需要进行广泛的研究，重点关注与危及生命的疾病发展相关的途径。本综述确定了与昼夜节律系统和睡眠中断相关的主要风险和相关因素。
