设计治疗性抗体以对抗传染病。
Engineering therapeutic antibodies to combat infectious diseases.
作者信息
Wagner Ellen K, Maynard Jennifer A
机构信息
Department of Chemical Engineering, The University of Texas at Austin, Austin TX USA, 78712.
出版信息
Curr Opin Chem Eng. 2018 Mar;19:131-141. doi: 10.1016/j.coche.2018.01.007. Epub 2018 Mar 7.
Abstract
Serum therapy fell out of favor 80 years ago, but antibodies against infectious diseases are now experiencing a renaissance. With the evolution of antibiotic-resistant bacteria, the emergence of new pathogens, and a growing population of immunocompromised individuals coupled with improvements in antibody manufacturing and biological efficacy, antibodies are an increasingly attractive therapeutic option. In this review, we highlight successful clinical strategies and discuss recent applications of advanced antibody engineering approaches to combat infectious diseases. Case studies include antibody mixtures to neutralize ; bispecific antibodies promoting clearance; antibody-antibiotic conjugates to eradicate from protected intracellular niches; and novel anti-RSV antibodies with extended serum half-life. These new designs are powerful strategies for targeting infectious diseases due to their abilities to target multiple antigens and induce novel clearance mechanisms.
摘要
血清疗法在80年前就失宠了，但如今针对传染病的抗体正经历复兴。随着耐药细菌的演变、新病原体的出现，以及免疫功能低下人群的增加，再加上抗体制造和生物学功效的改进，抗体成为越来越有吸引力的治疗选择。在本综述中，我们重点介绍了成功的临床策略，并讨论了先进抗体工程方法在对抗传染病方面的最新应用。案例研究包括用于中和的抗体混合物；促进清除的双特异性抗体；用于从受保护的细胞内微环境中根除的抗体-抗生素偶联物；以及具有延长血清半衰期的新型抗呼吸道合胞病毒抗体。这些新设计因其能够靶向多种抗原并诱导新的清除机制，是针对传染病的有力策略。
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