椎间盘老化、退变及相关潜在分子机制
Intervertebral Disc Aging, Degeneration, and Associated Potential Molecular Mechanisms.
作者信息
Wu Qiuqian, Huang Jason H
机构信息
Department of Neurosurgery, Baylor Scott and White Health, 5701 Airport Road, Temple, TX 76502.
出版信息
J Head Neck Spine Surg. 2017;1(4). doi: 10.19080/JHNSS.2017.01.555569. Epub 2017 Nov 16.
Abstract
Intervertebral disc degeneration is a major cause of neck and back pain, a very common clinical problem. However, no effective treatment is available, which is largely due to the lack of understanding of molecular mechanisms underlying disc degeneration. Here, we briefly described the process of intervertebral disc aging and degeneration and summarized major findings in molecular signaling pathways implicated in disc aging and degeneration.
摘要
椎间盘退变是颈部和背部疼痛的主要原因，这是一个非常常见的临床问题。然而，目前尚无有效的治疗方法，这在很大程度上是由于对椎间盘退变的分子机制缺乏了解。在此，我们简要描述了椎间盘老化和退变的过程，并总结了与椎间盘老化和退变相关的分子信号通路的主要研究结果。
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