CCPG1 是一种非典型自噬货物受体，对网质体自噬和胰腺内质网蛋白稳态至关重要。
CCPG1 is a noncanonical autophagy cargo receptor essential for reticulophagy and pancreatic ER proteostasis.
机构信息
a Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology , University of Michigan , Ann Arbor , MI , USA.
出版信息
Autophagy. 2018;14(7):1107-1109. doi: 10.1080/15548627.2018.1467199.
Abstract
Reticulophagy is the conserved macroautophagic/autophagic degradation of the endoplasmic reticulum (ER) in response to ER stress or general nutrient deprivation. Sequestration of the ER by phagophores plays an important role in regulating ER size and homeostasis. In their recent work, Smith et al. have discovered that the ER-localized protein CCPG1 is a novel mammalian reticulophagy receptor that interacts with core autophagy machinery components-LC3, GABARAP and RB1CC1-and regulates reticulophagy.
摘要
自噬是真核细胞中普遍存在的一种降解自身成分的生物学过程，通过形成双层膜结构的自噬体包裹待降解的细胞质成分或细胞器，然后与溶酶体融合形成自噬溶酶体，实现其降解。
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