小鼠催乳素和生长激素mRNA的核苷酸序列及其在妊娠期间的表达。
Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy.
作者信息
Linzer D I, Talamantes F
出版信息
J Biol Chem. 1985 Aug 15;260(17):9574-9.
PMID:2991252
Abstract
The mRNAs for mouse prolactin and growth hormone have been isolated from anterior pituitary glands and cloned as cDNAs. The nucleotide sequences of these mRNAs have been determined, and these sequences, along with the predicted amino acid sequences, are compared to those of other mammalian prolactin and growth hormone mRNAs. Levels of prolactin and growth hormone mRNAs during pregnancy have been monitored by hybridization to the cloned cDNA probes. We find the levels of these mRNAs to remain nearly constant during mid-to-late gestation.
摘要
已从小鼠垂体前叶中分离出催乳素和生长激素的信使核糖核酸（mRNA），并将其克隆为互补脱氧核糖核酸（cDNA）。已确定这些mRNA的核苷酸序列，并将这些序列以及预测的氨基酸序列与其他哺乳动物催乳素和生长激素的mRNA序列进行比较。通过与克隆的cDNA探针杂交，监测了怀孕期间催乳素和生长激素mRNA的水平。我们发现，在妊娠中期到晚期，这些mRNA的水平几乎保持不变。
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