Jacobsena Brit A, Dyb Grete, Hagen Knut, Stovner Lars J, Holmen Turid L, Zwart John-Anker
Department of Neurology, Vestfold Hospital, Tønsberg, Norway.
Faculty of Medicine, University of Oslo, Oslo, Norway.
Scand J Pain. 2018 Jul 1;2(3):148-152. doi: 10.1016/j.sjpain.2011.03.002.
Objective Earlier epidemiological studies have shown that headaches are frequent among adolescents, especially girls. In particular, recurrent primary headache disorders such as migraine and tension-type headaches are common complaints in this age group. Headaches are increasingly being recognized as a significant health problem in adolescents and can lead to significant disabilities by affecting their lives, their school performance and their social lives. The aim of this study was to compare the prevalence of primary headaches among adolescents aged 16-20 years in Norway in two periods. Very few replicate studies have re-evaluated the prevalence of primary headaches in this age range and it is uncertain whether the prevalence is increasing. Methods Two cross-sectional, population-based studies were conducted in Norway from 1995 to 1997 (Young-HUNT 1) and from 1999 to 2001 (Young-HUNT 2). In Young-HUNT 1, 2594 adolescents in 2nd and 3rd grade in upper secondary school (aged 16-20 years) completed a comprehensive questionnaire including one question regarding headache during the last 12 months. In addition, 1730 of the students were interviewed about their headache complaints. In Young-HUNT 2, 2373 adolescents aged 16-20 years completed the same questionnaire and 1655 were interviewed in the same way as the earlier survey. The interviews were performed by trained nurses, and respondents were asked if they had experienced recurrent headache during the last year. If so, the headache was classified as migraine (MI), tensiontype headache (TTH) or non-classifiable headache (NCH). Headache frequency during the past year was recorded according to the following categories: Less than 1 day per month (less than monthly), 1-3 days per month (monthly), 1-5 days per week (weekly), or more than 5 days per week (daily). Results The participation rate was 88% in Young-HUNT 1 and 81% in Young-HUNT 2. The overall prevalence of having had headaches during the last 12 months did not change significantly (79.4% versus 77.5%; OR: 0.89, 95%CI: 0.79-1.02, p = 0.09), whereas the prevalence of recurrent headaches increased from 30.3% in Young-HUNT 1 to 35.4% in Young-HUNT 2 (OR: 1.26, 95%CI: 1.09-1.46, p = 0.002). The prevalence of tension-type headache changed significantly from 19.0% to 21.9% (OR: 1.20, 95%CI: 1.02-1.42, p = 0.03). Also the prevalence of migraine tended to increase (7.5% versus 8.7%, OR: 1.18, 95%CI: 0.92-1.52, p = 0.18). The overall frequency of recurrent headache changed towards more monthly and less weekly headache. Conclusions This is the first large-scale population-based study among adolescents in Norway assessing changes in the prevalence of primary headaches over a four-year period of time. The overall prevalence of recurrent headaches increased significantly from Young-HUNT 1 to Young-HUNT 2. An increase was seen in all types of recurrent headaches and was significant for tension-type headache. Implications Earlier follow-up studies have examined changes in prevalence of recurrent headaches in young age, but the results are diverging. Our findings support the impression that the prevalence of recurrent headache among adolescents is increasing, and underlines the need for prospective designed studies with emphasis on prognosis and etiological factors.
目的 早期流行病学研究表明,头痛在青少年中很常见,尤其是女孩。特别是,偏头痛和紧张型头痛等复发性原发性头痛疾病是该年龄组的常见症状。头痛越来越被认为是青少年中的一个重大健康问题,并且会通过影响他们的生活、学业成绩和社交生活而导致严重的残疾。本研究的目的是比较挪威16 - 20岁青少年两个时期原发性头痛的患病率。很少有重复研究重新评估这个年龄范围内原发性头痛的患病率,患病率是否在增加尚不确定。
方法 1995年至1997年(青少年健康研究1)以及1999年至2001年(青少年健康研究2)在挪威进行了两项基于人群的横断面研究。在青少年健康研究1中,2594名高中二、三年级的青少年(年龄16 - 20岁)完成了一份综合问卷,其中包括一个关于过去12个月内头痛情况的问题。此外,对1730名学生进行了关于头痛症状的访谈。在青少年健康研究2中,2373名16 - 20岁的青少年完成了相同的问卷,并按照与早期调查相同的方式对1655名青少年进行了访谈。访谈由经过培训的护士进行,询问受访者在过去一年中是否经历过复发性头痛。如果是,头痛被分类为偏头痛(MI)、紧张型头痛(TTH)或不可分类头痛(NCH)。根据以下类别记录过去一年中的头痛频率:每月少于1天(少于每月)、每月1 - 3天(每月)、每周1 - 5天(每周)或每周超过5天(每天)。
结果 青少年健康研究1的参与率为88%,青少年健康研究2的参与率为81%。过去12个月内有头痛经历的总体患病率没有显著变化(79.4%对77.5%;OR:0.89,95%CI:0.79 - 1.02,p = 0.09),而复发性头痛的患病率从青少年健康研究1中的30.3%增加到青少年健康研究2中的35.4%(OR:1.26,95%CI:1.09 - 1.46,p = 0.002)。紧张型头痛的患病率从19.0%显著变化到21.9%(OR:1.20,95%CI:1.02 - 1.42,p = 0.03)。偏头痛的患病率也有增加的趋势(7.5%对8.7%,OR:1.18,95%CI:0.92 - 1.52,p = 0.18)。复发性头痛的总体频率朝着每月发作次数增多、每周发作次数减少的方向变化。
结论 这是挪威首次在青少年中进行的大规模基于人群的研究,评估了四年期间原发性头痛患病率的变化。从青少年健康研究1到青少年健康研究2,复发性头痛的总体患病率显著增加。所有类型的复发性头痛都有增加,紧张型头痛的增加具有显著性。
启示 早期的随访研究检查了年轻时复发性头痛患病率的变化,但结果存在分歧。我们的研究结果支持青少年复发性头痛患病率正在增加的观点,并强调需要进行前瞻性设计的研究,重点关注预后和病因因素。