Department of Emergency Medicine, Cathay General Hospital, Taipei, Taiwan.
Department of Emergency Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
Sci Rep. 2018 Jun 18;8(1):9312. doi: 10.1038/s41598-018-27694-6.
Although influenza may cause death in the geriatric population, the best method for predicting mortality in this population is still unclear. We retrospectively recruited older people (≥65 yr) with influenza visiting the emergency department (ED) of a medical center between January 1, 2010, and December 31, 2015. We performed univariate and multivariate logistic regression to identify independent mortality predictors and then developed a prediction score. Four hundred nine older ED patients with a nearly equal sex ratio were recruited. Five independent mortality predictors were identified: severe coma (Glasgow Coma Scale score ≤8), past histories of cancer and coronary artery disease, elevated C-reactive protein levels (>10 mg/dl), and bandemia (>10% band cells). We divided the patients into three mortality risk and disposition groups: (1) low risk (1.1%; 95% confidence interval [CI], 0.5-3.0%); (2) moderate risk (16.7%; 95% CI, 9.3-28.0%); and (3) high risk (40%; 95% CI, 19.8-64.2%). The area under the receiver operating characteristic curve and the Hosmer-Lemeshow goodness of fit of the GID score were 0.86 and 0.578, respectively. The GID score is an efficient and simple tool for predicting mortality in older ED patients with influenza. Further studies are warranted to validate its use.
虽然流感可能导致老年人群死亡,但预测该人群死亡率的最佳方法仍不清楚。我们回顾性招募了 2010 年 1 月 1 日至 2015 年 12 月 31 日期间因流感到医疗中心急诊科就诊的老年人(≥65 岁)。我们进行了单因素和多因素逻辑回归分析,以确定独立的死亡预测因素,然后制定了预测评分。共招募了 409 名性别比例几乎相等的老年 ED 患者。确定了 5 个独立的死亡预测因素:严重昏迷(格拉斯哥昏迷量表评分≤8)、癌症和冠心病病史、C 反应蛋白水平升高(>10mg/dl)和带状细胞增多(>10%带状细胞)。我们将患者分为三个死亡率和处置风险组:(1)低风险(1.1%;95%置信区间[CI],0.5-3.0%);(2)中风险(16.7%;95%CI,9.3-28.0%);和(3)高风险(40%;95%CI,19.8-64.2%)。GID 评分的受试者工作特征曲线下面积和 Hosmer-Lemeshow 拟合优度分别为 0.86 和 0.578。GID 评分是预测老年流感 ED 患者死亡率的有效且简单的工具。需要进一步的研究来验证其使用。