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从FBR小鼠骨肉瘤病毒中删除gag区域不会影响其增强的转化活性。

Deletion of the gag region from FBR murine osteosarcoma virus does not affect its enhanced transforming activity.

作者信息

Miller A D, Verma I M, Curran T

出版信息

J Virol. 1985 Sep;55(3):521-6. doi: 10.1128/JVI.55.3.521-526.1985.

DOI:10.1128/JVI.55.3.521-526.1985
PMID:2991577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254997/
Abstract

Both FBJ murine osteosarcoma virus (FBJ-MSV) and FBR-MSV induce transformation in tissue culture and osteogenic sarcomas in mice. In tissue culture, however, FBR-MSV induces larger foci with a shorter latency than those induced by FBJ-MSV. Transformation is dependent on expression of the fos oncogene in FBJ-MSV and of a gag-fos fusion protein in FBR-MSV. We have determined that the gag sequences can be deleted from FBR-MSV without affecting the high transforming activity of this virus in comparison to FBJ-MSV. The resultant virus, designated FBJ/R-MSV, has a protein coding region that is half the size of that of FBR-MSV and about one-third smaller than that of FBJ-MSV. Thus, FBJ/R-MSV will provide a useful tool for studying the transforming activity of the fos oncogene.

摘要

FBJ小鼠骨肉瘤病毒（FBJ-MSV）和FBR-MSV均可在组织培养中诱导细胞转化，并在小鼠中诱发骨肉瘤。然而，在组织培养中，FBR-MSV诱导的病灶比FBJ-MSV诱导的病灶更大，潜伏期更短。转化依赖于FBJ-MSV中fos癌基因的表达以及FBR-MSV中gag-fos融合蛋白的表达。我们已经确定，可以从FBR-MSV中删除gag序列，而与FBJ-MSV相比，这并不影响该病毒的高转化活性。所得病毒命名为FBJ/R-MSV，其蛋白质编码区大小是FBR-MSV的一半，比FBJ-MSV小约三分之一。因此，FBJ/R-MSV将为研究fos癌基因的转化活性提供一个有用的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7c/254997/d8b599aad995/jvirol00120-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7c/254997/b4c855cdffc0/jvirol00120-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7c/254997/d8b599aad995/jvirol00120-0019-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7c/254997/b4c855cdffc0/jvirol00120-0018-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d7c/254997/d8b599aad995/jvirol00120-0019-a.jpg

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Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini.对FBJ-鼠肉瘤病毒前病毒和c-fos（小鼠）基因的分析表明，病毒和细胞的fos基因产物具有不同的羧基末端。
Cell. 1983 Apr;32(4):1241-55. doi: 10.1016/0092-8674(83)90306-9.
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FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA.FBJ小鼠骨肉瘤病毒：具有生物活性的前病毒DNA的鉴定与分子克隆
J Virol. 1982 Nov;44(2):674-82. doi: 10.1128/JVI.44.2.674-682.1982.
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