Department of Neurosurgery, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan.
Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan.
Acta Neurochir (Wien). 2018 Aug;160(8):1557-1561. doi: 10.1007/s00701-018-3598-5. Epub 2018 Jun 19.
Although liposarcomas are the most common soft tissue sarcomas, their intracranial variants are extremely rare. Here, we present a case of a primary intracranial myxoid liposarcoma in a 23-year-old Japanese man who presented with generalized seizures and a mass in the left frontal lobe. The tumor was totally removed, and histological analyses pointed to liposarcoma. Thirteen years after his initial treatment, the patient presented with right-side weakness and local recurrence of tumor was discovered. Histology from the second resection confirmed the diagnosis of myxoid liposarcoma. Shortly after the second resection, progressive, new intracranial lesions were observed and despite a third resection, extensive intracerebral invasion by the tumor proved fatal. The histological features of myxoid liposarcoma were essentially similar with each recurrence, but the aggressive tumor behavior after the second operation did not align with expectations based on histological classification.
虽然脂肪肉瘤是最常见的软组织肉瘤，但颅内变体极为罕见。在这里，我们报告了一名 23 岁日本男性的原发性颅内黏液样脂肪肉瘤病例，他表现为全身发作和左额叶肿块。肿瘤被完全切除，组织学分析提示为脂肪肉瘤。在初始治疗后 13 年，患者出现右侧无力，发现肿瘤局部复发。第二次切除的组织学证实了黏液样脂肪肉瘤的诊断。第二次切除后不久，观察到进行性新的颅内病变，尽管进行了第三次切除，但肿瘤广泛侵犯颅内导致患者死亡。黏液样脂肪肉瘤的组织学特征在每次复发时基本相似，但第二次手术后肿瘤的侵袭性行为与基于组织学分类的预期不符。
