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对埃可病毒（鼠痘）病毒诱导死亡率抗性的遗传决定因素。

Genetic determinants of resistance to ectromelia (mousepox) virus-induced mortality.

作者信息

Wallace G D, Buller R M, Morse H C

出版信息

J Virol. 1985 Sep;55(3):890-1. doi: 10.1128/JVI.55.3.890-891.1985.

DOI:10.1128/JVI.55.3.890-891.1985
PMID:2991610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC255083/
Abstract

Resistance to ectromelia (mousepox) virus-induced mortality was examined in crosses between susceptible DBA/2J, A/J, and BALB/cByJ mice and resistant C57BL/6J and AKR/J mice. Depending on the cross, resistance to mousepox virus was shown to be determined by one or more independently assorting autosomal loci with dominant alleles for resistance in AKR/J and C57BL/6J mice and recessive alleles in A/J, BALB/cByJ, and DBA/2J mice. A sexual dimorphism in resistance to disease was also observed.

摘要

在易感性的DBA/2J、A/J和BALB/cByJ小鼠与抗性的C57BL/6J和AKR/J小鼠的杂交实验中，研究了对埃可病毒（鼠痘）诱导死亡的抗性。根据杂交情况，对鼠痘病毒的抗性显示由一个或多个独立分离的常染色体基因座决定，在AKR/J和C57BL/6J小鼠中抗性由显性等位基因决定，而在A/J、BALB/cByJ和DBA/2J小鼠中由隐性等位基因决定。还观察到了对疾病抗性的性别二态性。

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Genetic determinants of resistance to ectromelia (mousepox) virus-induced mortality.对埃可病毒（鼠痘）病毒诱导死亡率抗性的遗传决定因素。
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