CNRS UMR8261, Associated with University Paris Diderot, Sorbonne Paris Cité, Institut de Biologie Physico-Chimique, 75005 Paris, France.
Microbiol Spectr. 2018 May;6(3). doi: 10.1128/microbiolspec.RWR-0014-2017.
Small regulatory RNAs are now recognized as key regulators of gene expression in bacteria. They accumulate under specific conditions, most often because their synthesis is directly controlled by transcriptional regulators, including but not limited to alternative sigma factors and response regulators of two-component systems. In turn, small RNAs regulate, mostly at the posttranscriptional level, expression of multiple genes, among which are genes encoding transcriptional regulators. Small RNAs are thus embedded in mixed regulatory circuits combining transcriptional and posttranscriptional controls, and whose properties are discussed here.
现在，小分子 RNA 被认为是细菌中基因表达的关键调控因子。它们在特定条件下积累，这种情况最常发生是因为它们的合成受到转录调控因子的直接控制，包括但不限于替代 sigma 因子和双组分系统的反应调节因子。反过来，小分子 RNA 主要在转录后水平上调节多个基因的表达，其中包括编码转录调控因子的基因。因此，小分子 RNA 被嵌入到混合调控回路中，该回路结合了转录和转录后控制，这里将讨论其特性。
