Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Phytother Res. 2018 Oct;32(10):1983-1991. doi: 10.1002/ptr.6127. Epub 2018 Jun 19.
Cinnamomum zeylanicum (cinnamon) is a plant with potent antioxidant activity and has been used in traditional medicine for improvement of heart function. The effects of cinnamon bark ethanolic extract were investigated against ischemia-induced arrhythmias and heart injury in an in vivo rat model of regional heart ischemia. The extract was also standardized, and its antioxidant activity was evaluated. Adult male Sprague-Dawley rats were subjected to 30 min of ischemia by occlusion of the left anterior descending coronary artery followed by 5 days of reperfusion. Thirty-two animals were randomized to receive daily oral administration of vehicle or C. zeylanicum bark extract (intragastric, 50, 100, or 200 mg/kg) 14 days before ischemia. C. zeylanicum was standardized through HPLC analysis. Administration of cinnamon bark extract significantly improved ischemia/reperfusion-induced myocardial injury as evidenced by reduction of the infarct size. Also, during the ischemic period, ventricular tachycardia and ventricular ectopic beats episodes decreased as compared with that of the control group. The extract stabilized the ST segment changes and QTc shortening, decreased R-wave amplitude, and increased heart rate during ischemia. The extract also caused significant elevations in serum superoxide dismutase and glutation proxidase activities as well as a significant decrease in serum cardiac troponin I, lactate dehydrogenase, and malondialdehyde levels, 5 days after reperfusion. In HPLC analysis, the amounts of Cinamic acid, Methyl eugenol, and Cinnamaldehyde were 8.99 ± 0.5, 13.02 ± 1.8, and 14.63 ± 1.1 mg/g, respectively. The results show that the ethanolic extract of cinnamon bark is able to protect the heart against ischemia-reperfusion injury probably due to its antioxidant properties. Hence, it might be beneficial in these patients and this remedy might be used for preparation of new drugs.
肉桂（肉桂）是一种具有强大抗氧化活性的植物，已在传统医学中用于改善心脏功能。研究了肉桂树皮乙醇提取物对局部心肌缺血大鼠模型中缺血性心律失常和心脏损伤的作用。还对提取物进行了标准化，并评估了其抗氧化活性。雄性 Sprague-Dawley 大鼠通过结扎左前降支冠状动脉缺血 30 分钟，然后再灌注 5 天。32 只动物随机接受每日口服溶剂或肉桂树皮提取物（胃内，50、100 或 200mg/kg），在缺血前 14 天。通过 HPLC 分析对肉桂进行了标准化。肉桂树皮提取物的给药显著改善了缺血/再灌注引起的心肌损伤，表现为梗死面积减少。此外，与对照组相比，在缺血期间，室性心动过速和室性期前收缩发作减少。提取物在缺血期间稳定 ST 段变化和 QTc 缩短，降低 R 波幅度，并增加心率。提取物还导致再灌注后 5 天血清超氧化物歧化酶和谷胱甘肽过氧化物酶活性显著升高，血清肌钙蛋白 I、乳酸脱氢酶和丙二醛水平显著降低。在 HPLC 分析中，肉桂酸、甲基丁香酚和肉桂醛的含量分别为 8.99±0.5、13.02±1.8 和 14.63±1.1mg/g。结果表明，肉桂树皮的乙醇提取物能够保护心脏免受缺血再灌注损伤，可能是由于其抗氧化特性。因此，它可能对这些患者有益，这种疗法可用于制备新药。
