Moreira Laís de Souza Gouveia, Brum Isabela de Souza da Costa, de Vargas Reis Drielly C M, Trugilho Liana, Chermut Tuany R, Esgalhado Marta, Cardozo Ludmila F M F, Stenvinkel Peter, Shiels Paul G, Mafra Denise
Graduate Program in Medical Sciences, Fluminense Federal University, Niterói, Brazil.
Graduate Program in Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Kidney Res Clin Pract. 2023 Jan;42(1):4-26. doi: 10.23876/j.krcp.22.111. Epub 2023 Jan 31.
Cinnamon, a member of the Lauraceae family, has been widely used as a spice and traditional herbal medicine for centuries and has shown beneficial effects in cardiovascular disease, obesity, and diabetes. However, its effectiveness as a therapeutic intervention for chronic kidney disease (CKD) remains unproven. The bioactive compounds within cinnamon, such as cinnamaldehyde, cinnamic acid, and cinnamate, can mitigate oxidative stress, inflammation, hyperglycemia, gut dysbiosis, and dyslipidemia, which are common complications in patients with CKD. In this narrative review, we assess the mechanisms by which cinnamon may alleviate complications observed in CKD and the possible role of this spice as an additional nutritional strategy for this patient group.
肉桂是樟科植物的一种,几个世纪以来一直被广泛用作香料和传统草药,并且已在心血管疾病、肥胖症和糖尿病方面显示出有益效果。然而,其作为慢性肾脏病(CKD)治疗干预措施的有效性仍未得到证实。肉桂中的生物活性化合物,如肉桂醛、肉桂酸和肉桂酸盐,可以减轻氧化应激、炎症、高血糖、肠道菌群失调和血脂异常,这些都是CKD患者常见的并发症。在这篇叙述性综述中,我们评估了肉桂可能缓解CKD中观察到的并发症的机制,以及这种香料作为该患者群体额外营养策略的潜在作用。