Alibaba Business School, Hangzhou Normal University, Hangzhou 310000, China.
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning 53000, China.
Comput Math Methods Med. 2023 Feb 23;2023:1066057. doi: 10.1155/2023/1066057. eCollection 2023.
Myocardial ischemia-reperfusion injury (MIRI) is a common complication of acute myocardial infarction that seriously endangers human health. Cinnamon, a traditional Chinese medicine, has been used to counteract MIRI as it has been shown to possess anti-inflammatory and antioxidant properties. To investigate the mechanisms of action of cinnamon in the treatment of MIRI, a deep learning-based network pharmacology method was established to predict potential active compounds and targets. The results of the network pharmacology showed that oleic acid, palmitic acid, beta-sitosterol, eugenol, taxifolin, and cinnamaldehyde were the main active compounds, and phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt), mitogen-activated protein kinase (MAPK), interleukin (IL)-7, and hypoxia-inducible factor 1 (HIF-1) are promising signaling pathways. Further molecular docking tests revealed that these active compounds and targets exhibited good binding abilities. Finally, experimental validation using a zebrafish model demonstrated that taxifolin, the active compound of cinnamon, has a potential protective effect against MIRI.
心肌缺血再灌注损伤（MIRI）是急性心肌梗死的常见并发症，严重危害人类健康。肉桂作为一种传统中药，具有抗炎和抗氧化作用，已被用于对抗 MIRI。为了研究肉桂治疗 MIRI 的作用机制，建立了基于深度学习的网络药理学方法来预测潜在的活性化合物和靶点。网络药理学的结果表明，油酸、棕榈酸、β-谷甾醇、丁香酚、杨梅素和肉桂醛是主要的活性化合物，磷脂酰肌醇-3 激酶（PI3K）/蛋白激酶 B（Akt）、丝裂原活化蛋白激酶（MAPK）、白细胞介素（IL）-7 和缺氧诱导因子 1（HIF-1）是有前途的信号通路。进一步的分子对接测试表明，这些活性化合物和靶点具有良好的结合能力。最后，使用斑马鱼模型进行的实验验证表明，肉桂的活性化合物杨梅素对 MIRI 具有潜在的保护作用。
