中枢多巴胺能系统在H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH行为效应中的作用。
The role of central dopaminergic systems in the behavioral effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH.
作者信息
Vécsei L, Telegdy G, Bollók I, Schally A V
出版信息
Neuropeptides. 1985 Jun;6(3):183-90. doi: 10.1016/0143-4179(85)90089-7.
In the present study the role of the central dopaminergic systems in the behavioral action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was investigated. The heptapeptide inhibited the extinction of active avoidance behavior if the treatment was performed intracerebroventricularly (icv) in a dose of 1 microgram, but was ineffective in a dose of 0.1 micrograms. If the peptide was injected into the nucleus accumbens septi (NAS) in a dose of 1 microgram, 0.1 micrograms or 0.01 micrograms it inhibited the extinction, but in the latter dose its effect was only a short one. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH in a dose of 1 microgram, 10 micrograms or 20 micrograms (icv) did not influence the turning activity of unilateral substantia nigra (USN)-lesioned animals. These results suggest that the NAS plays an important role in the behavioral action of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH and the heptapeptide has no direct dopamine receptor stimulatory or dopamine-releasing effect in the striatum.
在本研究中，对中枢多巴胺能系统在H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH行为作用中的角色进行了研究。如果以1微克的剂量进行脑室内（icv）给药，该七肽可抑制主动回避行为的消退，但0.1微克的剂量则无效。如果将该肽以1微克、0.1微克或0.01微克的剂量注入伏隔核（NAS），它会抑制消退，但在后者剂量下其作用只是短暂的。1微克、10微克或20微克（icv）剂量的H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH对单侧黑质（USN）损伤动物的旋转活动没有影响。这些结果表明，NAS在H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH的行为作用中起重要作用，且该七肽在纹状体中没有直接的多巴胺受体刺激或多巴胺释放作用。
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