Telegdy G, Vécsei L, Schally A V
Department of Pathophysiology, University Medical School, Szeged, Hungary.
Acta Physiol Hung. 1988;72(3-4):315-20.
H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH after intracerebroventricular (icv.) administration inhibited the extinction of active avoidance behaviour for a short period. The dopamine receptor blocker haloperidol completely blocked this effect of the heptapeptide, while the muscarinic anticholinergic agent atropine only partly inhibited it. The alpha 1-receptor blocker phenoxybenzamine and the beta-receptor blocker propranolol did not significantly influence the extinction inhibition induced by the peptide. These results suggest that the dopaminergic and, in part the cholinergic system, play important roles in this behavioural action of H-Phe-Ile-Tyr-Ser-Tyr-Lys-OH.
脑室内注射H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH后，在短时间内抑制了主动回避行为的消退。多巴胺受体阻滞剂氟哌啶醇完全阻断了七肽的这种作用，而毒蕈碱抗胆碱能药物阿托品仅部分抑制了它。α1受体阻滞剂酚苄明和β受体阻滞剂普萘洛尔对该肽诱导的消退抑制没有显著影响。这些结果表明，多巴胺能系统以及部分胆碱能系统在H-Phe-Ile-Tyr-Ser-Tyr-Lys-OH的这种行为作用中起重要作用。
