Telegdy G, Vécsei L, Schally A V, Coy D H
Neuropharmacology. 1983 Jan;22(1):131-4. doi: 10.1016/0028-3908(83)90273-3.
beta-(Tyr9)melanotropin-(9-18), which itself has no analgesic action, as measured by the tail-flick and hot-plate methods, decreased morphine-induced analgesia following intracerebroventricular injection. H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH heptapeptide, which has weak CRF-like activity, had no action on analgesia and was not able to modify morphine-induced analgesia. Compared with ACTH1-24, which in a subcutaneous dose of 100 micrograms/rat decreased morphine-induced analgesia, the same dose of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH was ineffective.
β-（酪氨酰⁹）促黑素-（9-18），通过甩尾法和热板法测定，其本身并无镇痛作用，但脑室内注射后会降低吗啡诱导的镇痛效果。具有弱促肾上腺皮质激素释放因子（CRF）样活性的七肽H-苯丙氨酸-异亮氨酸-酪氨酸-组氨酸-丝氨酸-酪氨酸-赖氨酸-OH，对镇痛无作用，也无法改变吗啡诱导的镇痛效果。皮下注射剂量为100微克/大鼠时，促肾上腺皮质激素1-24会降低吗啡诱导的镇痛效果，而相同剂量的H-苯丙氨酸-异亮氨酸-酪氨酸-组氨酸-丝氨酸-酪氨酸-赖氨酸-OH则无效。
