Telegdy G, Vécsei L, Bollók I, Schally A V
Neuropeptides. 1985 Sep;6(5):417-24. doi: 10.1016/0143-4179(85)90140-4.
In this study the effects of beta-(Tyr9)MSH-9-18 administered intracerebroventricularly (icv) or into the nucleus accumbens septi (NAS) were investigated on active and passive avoidance behavior of rats. This hypothalamic decapeptide in a dose of 1.0 microgram (icv) inhibited the extinction of active avoidance behavior however, in a dose of 0.1 microgram (icv) it was ineffective. The peptide injected into the NAS in a dose of 0.1 microgram had a same inhibitory effect but in a dose of 0.01 microgram this inhibitory effect was only a short lasting one. In the passive avoidance behavior the peptide in a dose of 1 microgram and 0.1 microgram (icv) significantly increased the passive avoidance latency, but in a dose of 0.01 microgram it was ineffective. If the same doses of the decapeptide were injected into the NAS the peptide was ineffective. These results suggest that the NAS doses not play a role in the memory effect of beta-(Tyr9)MSH9-18 and memory compound does not participate in the NAS mediated effect of the decapeptide on the active avoidance behavior.
在本研究中，研究了脑室内（icv）或伏隔核（NAS）注射β-（Tyr9）MSH-9-18对大鼠主动和被动回避行为的影响。剂量为1.0微克（icv）的这种下丘脑十肽抑制了主动回避行为的消退，然而，剂量为0.1微克（icv）时则无效。以0.1微克的剂量注入NAS的该肽具有相同的抑制作用，但剂量为0.01微克时，这种抑制作用只是短暂的。在被动回避行为中，剂量为1微克和0.1微克（icv）的该肽显著增加了被动回避潜伏期，但剂量为0.01微克时则无效。如果将相同剂量的十肽注入NAS，该肽则无效。这些结果表明，NAS在β-（Tyr9）MSH9-18的记忆效应中不起作用，且记忆化合物不参与十肽对主动回避行为的NAS介导效应。
