The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.
Tetranov Biopharm, LLC. and Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou , 450052 , People's Republic of China.
Org Lett. 2018 Jul 6;20(13):3732-3735. doi: 10.1021/acs.orglett.8b01216. Epub 2018 Jun 19.
An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.
发展了一种高效的镍催化 C-H 三氟甲基化反应，用于使用 Togni's 试剂合成三氟甲基化的游离苯胺。该方法在温和条件下具有良好的官能团耐受性、良好的区域选择性和化学选择性。新开发的经济一步法是合成三氟甲基化游离苯胺的更好选择。
