Ohnishi A, Ishibashi H, Ohtani K, Matsunaga K, Yamamoto T
J UOEH. 1985 Jun 1;7(2):201-5. doi: 10.7888/juoeh.7.201.
Clinical cases of sensory neuropathy produced by a megadose of vitamin B6 have been reported in English literatures. We investigated the ordinary daily dosage and maximal dose of vitamin B6 widely adopted in Japan, and the amount of vitamin B6 per unit (per tablet, capsule or ampule) available in our medical practice. We concluded that in Japan it is very rare to administer such a large dose of vitamin B6 that produced sensory neuropathy described in the literatures. In our experimental study, Sprague-Dawley rats were intraperitoneally given a total amount of 14,000 mg/kg of body weight of pyridoxine hydrochloride in ten separate doses. They developed an ataxic gait. The occurrence of the degeneration of nerve cell bodies and peripheral axons of lumbar primary sensory neurons were histologically demonstrated. Although in Japan no clinical cases of neuropathy produced by a megadose of vitamin B6 have been reported to our knowledge, it is necessary to be aware of the possible occurrence of such neuropathy among patients with polyneuropathy of unknown etiology or who have been receiving vitamin B6 for a long time.
英文文献中已报道了因大剂量维生素B6导致感觉神经病变的临床病例。我们调查了日本广泛采用的维生素B6的日常常规剂量和最大剂量，以及我们医疗实践中每单位（每片、胶囊或安瓿）维生素B6的含量。我们得出结论，在日本，给予文献中描述的导致感觉神经病变的如此大剂量的维生素B6是非常罕见的。在我们的实验研究中，将总共14,000 mg/kg体重的盐酸吡哆醇分十次腹腔注射给予斯普拉格-道利大鼠。它们出现了共济失调步态。组织学证实了腰段初级感觉神经元的神经细胞体和周围轴突发生了退化。尽管据我们所知在日本尚未有因大剂量维生素B6导致神经病变的临床病例报道，但对于病因不明的多发性神经病患者或长期接受维生素B6治疗的患者，有必要意识到可能会发生此类神经病变。
