Sabbaghian Marjan, Mohseni Meybodi Anahita, Rafaee Alemeh, Saba Sadaf, Zamanian Mohammadreza, Sadighi Gilani Mohammad Ali
Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Andrologia. 2018 Sep;50(7):e13052. doi: 10.1111/and.13052. Epub 2018 Jun 19.
To evaluate the success rate in sperm retrieval (SR) through microdissection testicular sperm extraction (micro-TESE) in infertile azoospermia factor c (AZFc)-deleted men and determining their reproductive outcomes following ICSI, medical records of couples with AZFc-deleted male partners were reviewed on patient's age, serum hormone levels, karyotype, testicular pathology and pregnancy outcomes. A comparison on age and serum hormone level was conducted between groups with positive and negative sperm retrieval in both azoospermic and oligozoospermic AZFc-deleted men. Of 225 who had AZFc deletion, 195 cases followed clinical treatments. From 195 cases, 116 were azoospermic, 79 were oligozoospermic. Pathology profile was available in 103 of 195 subjects which the predominant trait was SCOS and was seen in 66.9% of cases (69 of 103). Success rate of sperm retrieval in azoospermic patients who underwent micro-TESE was 36.3% (28/77). Forty-three oligozoospermic and 17 azoospermic patients started ART cycle. Pregnancy rate in oligozoospermic group was 35.4% (17 cases), whilst there was no clinical pregnancy in azoospermic group. In conclusion, the pregnancy and delivery in oligozoospermic patients with AZFc deletion are comparable with other studies, but despite of sperm retrieval in azoospermic patients with AZFc deletion, the chance of pregnancy or delivery in these patients was very low.
为评估在不育的无精子症因子c（AZFc）缺失男性中，通过显微切割睾丸精子提取术（micro-TESE）进行精子获取（SR）的成功率，并确定其在卵胞浆内单精子注射（ICSI）后的生殖结局，我们回顾了男性伴侣为AZFc缺失的夫妇的病历，记录患者年龄、血清激素水平、核型、睾丸病理及妊娠结局。对无精子症和少精子症的AZFc缺失男性中精子获取阳性和阴性的两组患者进行年龄和血清激素水平比较。在225例存在AZFc缺失的患者中，195例接受了临床治疗。其中116例为无精子症，79例为少精子症。195例受试者中有103例有病理资料，主要特征是生精细胞发育不全（SCOS），见于66.9%的病例（103例中的69例）。接受micro-TESE的无精子症患者精子获取成功率为36.3%（28/77）。43例少精子症患者和17例无精子症患者开始辅助生殖周期。少精子症组的妊娠率为35.4%（17例），而无精子症组无临床妊娠。总之，AZFc缺失的少精子症患者的妊娠和分娩情况与其他研究相当，但尽管AZFc缺失的无精子症患者能获取精子，这些患者的妊娠或分娩几率非常低。
