Danilova R A, Gurevich E V, Storozheva Z I
Zh Vyssh Nerv Deiat Im I P Pavlova. 1985 Mar-Apr;35(2):267-71.
The influence of cAMP analogue 8-Br-cAMP on conditioning was studied in white rats. Two models of learning were used with different kinds of reinforcement, i. e. conditioned active avoidance and instrumental alimentary reactions in a complex maze. Intraventricular 8-Br-cAMP injection 4 or 24 hours before the beginning of learning improved the process of defensive as well as alimentary conditioning. Characteristics of formation of complex behaviour of experimental rats in a maze showed that under the influence of 8-Br-cAMP, not only conditioning was accelerated, but the process of optimal decision making itself was changed. The data obtained permit to suppose that 8-Br-cAMP first of all affects initially poorly learning rats.
研究了环磷酸腺苷（cAMP）类似物8-溴环磷酸腺苷（8-Br-cAMP）对大白鼠条件反射的影响。采用了两种不同强化方式的学习模型，即条件性主动回避和复杂迷宫中的工具性食物反应。在学习开始前4小时或24小时脑室内注射8-Br-cAMP可改善防御性和食物性条件反射过程。实验大鼠在迷宫中复杂行为形成的特征表明，在8-Br-cAMP的影响下，不仅条件反射加速，而且最佳决策过程本身也发生了变化。所获得的数据表明，8-Br-cAMP首先影响最初学习能力较差的大鼠。
