Ferreira Guilherme A, Felippe Leandro C, Bertuzzi Rômulo, Bishop David J, Barreto Emiliano, De-Oliveira Fernando R, Lima-Silva Adriano E
Sports Science Research Group, Academic Center of Vitoria, Federal University of Pernambuco, Recife, Brazil.
Endurance Performance Research Group, School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Front Physiol. 2018 Jun 5;9:671. doi: 10.3389/fphys.2018.00671. eCollection 2018.
We examined the effect of acute and chronic sprint interval training (SIT), with or without prior caffeine intake, on levels of exercise-induced inflammatory plasma cytokines [interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α]. Twenty physically-active men ingested either a placebo ( = 10) or caffeine ( = 10) 1 h before each SIT session(13-s × 30-s sprint/15 s of rest) during six training sessions (2 weeks). The early (before, immediately after, and 45 min after the exercise) and late (24 and 48 h after the exercise) cytokine and creatine kinase (CK) responses were analyzed for the first and last training sessions. Plasma IL-6 and IL-10 peaked 45 min after the exercise, and then returned to basal values within 24 h ( < 0.05) in both groups on both occasions ( > 0.05). On both occasions, and for both groups, plasma TNF-α increased from rest to immediately after the exercise and then decreased at 45 min before reaching values at or below basal levels 48 h after the exercise ( < 0.05). Serum CK increased from rest to 24 and 48 h post-exercise in the first training session ( < 0.05), but did not alter in the last training session for the PLA group ( > 0.05). Serum CK was unchanged in both the first and last training sessions for the CAF group ( > 0.05). Two weeks of SIT induced a late decrease in the IL-6/IL-10 ratio ( < 0.05) regardless of caffeine intake, suggesting an improved overall inflammatory status after training. In conclusion, a single session of SIT induces muscle damage that seems to be mitigated by caffeine intake. Two weeks of SIT improves the late SIT-induced muscle damage and inflammatory status, which seems to be independent of caffeine intake.
我们研究了急性和慢性冲刺间歇训练（SIT）在摄入或未摄入咖啡因前对运动诱导的血浆炎症细胞因子[白细胞介素（IL）-6、IL-10、肿瘤坏死因子（TNF）-α]水平的影响。20名身体活跃的男性在六个训练阶段（2周）的每次SIT训练（13秒×30秒冲刺/15秒休息）前1小时摄入安慰剂（n = 10）或咖啡因（n = 10）。对第一次和最后一次训练阶段的早期（运动前、运动后即刻和运动后45分钟）和晚期（运动后24小时和48小时）细胞因子和肌酸激酶（CK）反应进行了分析。两组在两次实验中，血浆IL-6和IL-10在运动后45分钟达到峰值，然后在24小时内恢复到基础值（P < 0.05）（P > 0.05）。在两次实验中，两组的血浆TNF-α均从静息状态增加到运动后即刻，然后在45分钟时下降，在运动后48小时达到或低于基础水平（P < 0.05）。在第一次训练阶段，血清CK从静息状态增加到运动后24小时和48小时（P < 0.05），但在PLA组的最后一次训练阶段没有变化（P > 0.05）。CAF组在第一次和最后一次训练阶段血清CK均无变化（P > 0.05）。两周的SIT诱导IL-6/IL-10比值出现晚期下降（P < 0.05），与咖啡因摄入无关，表明训练后整体炎症状态得到改善。总之，单次SIT会引起肌肉损伤，而咖啡因摄入似乎可以减轻这种损伤。两周的SIT可改善SIT后期引起的肌肉损伤和炎症状态，这似乎与咖啡因摄入无关。
