Aslani Abolfazl, Zolfaghari Behzad, Fereidani Yeganeh
Department of Pharmaceutics, Novel Drug Delivery Systems Research Center, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Dent Res J (Isfahan). 2018 May-Jun;15(3):191-200. doi: 10.4103/1735-3327.231865.
The herpes simplex virus is a human pathogen which can cause skin or mucous membrane infections. Melissa, sumac, licorice, rosemary, and geranium have antimicrobial, antiviral, anti-inflammatory, and local analgesic effect. Shortening recovery period of recurrent herpes labialis and control of viral protein formation are the other effects of these herbs. The aim of this study is design, formulation, and evaluation of the gel containing extracts of these five herbs.
In this experimental study after photochemical and macroscopic evaluation of these medicinal herbs, the semisolid concentrated extracts were incorporated in gel bases. Mucoadhesive gels were prepared using carbopol 940, sodium carboxymethylcellulose (Na CMC) and hydroxypropyl methylcellulose K4M as bioadhesive polymers. Physicochemical tests, viscosity, mucoadhesive strength measurement, and drug release study were carried out on formulations F (carbopol 940, 0.5% and Na CMC, 3%) and F (carbopol 940, 1% and Na CMC, 3%).
Polyphenol content of extracts mixture was measured 210.8 ± 13.68 mg GAE/g. pH of formulations was 6.0 ± 0.2. 14 gel formulations were prepared. Physical appearance, homogeneity, and consistency of F and F were good. Mucoadhesion and viscosity of F was more than F. Study of release profiles in F and F formulations showed drug release from F was slower.
The best formulation for treatment and shortening recovery period of recurrent labial herpes infections should exhibit high value of mucoadhesion, show controlled release of drug. F with the highest viscosity and mucoadhesion and the lowest release rate was considered as the best formulation.
单纯疱疹病毒是一种可导致皮肤或黏膜感染的人类病原体。蜜蜂花、漆树、甘草、迷迭香和天竺葵具有抗菌、抗病毒、抗炎和局部镇痛作用。缩短复发性唇疱疹的恢复期以及控制病毒蛋白形成是这些草药的其他作用。本研究的目的是设计、制备并评价含有这五种草药提取物的凝胶。
在本实验研究中，对这些草药进行光化学和宏观评估后，将半固体浓缩提取物加入凝胶基质中。使用卡波姆940、羧甲基纤维素钠（Na CMC）和羟丙基甲基纤维素K4M作为生物黏附聚合物制备黏膜黏附凝胶。对配方F（卡波姆940，0.5%和Na CMC，3%）和配方F（卡波姆940，1%和Na CMC，3%）进行物理化学测试、黏度、黏膜黏附强度测量和药物释放研究。
提取物混合物的多酚含量测定为210.8±13.68 mg GAE/g。配方的pH值为6.0±0.2。制备了14种凝胶配方。配方F和F的外观、均匀性和稠度良好。配方F的黏膜黏附性和黏度高于配方F。配方F和F的释放曲线研究表明，配方F的药物释放较慢。
用于治疗和缩短复发性唇疱疹感染恢复期的最佳配方应具有高黏膜黏附性，显示药物控释。黏度和黏膜黏附性最高且释放速率最低的配方F被认为是最佳配方。
