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药用口香糖,一种新型药物递送系统。

Medicated chewing gum, a novel drug delivery system.

作者信息

Aslani Abolfazl, Rostami Farnaz

机构信息

Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran ; Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

J Res Med Sci. 2015 Apr;20(4):403-11.

Abstract

New formulations and technologies have been developed through oral drug delivery systems' researches. Such researches display significance of oral route amongst patients. We've reviewed all the features associated with medicated chewing gum as a modern drug delivery by introducing the history, advantages and disadvantages, methods of manufacturing, composition differences, evaluation tests and examples of varieties of medicated chewing gums. Acceptance of medicated chewing gum has been augmented through years. The advantages and therapeutic benefits of chewing gum support its development as we can see new formulations with new drugs contained have been produced from past and are going to find a place in market by formulation of new medicated chewing gums. Potential applications of medicated chewing gums are highly widespread as they will be recognized in future. Nowadays standards for qualifying chewing gums are the same as tablets. Patient-centered studies include medicated chewing gums as a delivery system too which creates compliance for patients.

摘要

通过口服给药系统的研究,已经开发出了新的制剂和技术。这类研究显示了口服途径在患者中的重要性。通过介绍药用口香糖作为一种现代药物递送方式的历史、优缺点、制造方法、成分差异、评估测试以及各类药用口香糖的实例,我们回顾了与药用口香糖相关的所有特性。多年来,药用口香糖的接受度一直在提高。口香糖的优点和治疗益处支持了其发展,因为我们可以看到,过去已经生产出了含有新药的新制剂,并且通过新药用口香糖的配方,它们将在市场上占据一席之地。药用口香糖的潜在应用非常广泛,因为它们在未来将会得到认可。如今,口香糖的质量标准与片剂相同。以患者为中心的研究也将药用口香糖作为一种递送系统,这提高了患者的依从性。

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本文引用的文献

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Design, formulation, and evaluation of ginger medicated chewing gum.生姜药用口香糖的设计、配方及评估
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Design, formulation and evaluation of green tea chewing gum.绿茶口香糖的设计、配方及评估
Adv Biomed Res. 2014 Jun 25;3:142. doi: 10.4103/2277-9175.135159. eCollection 2014.
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Design, formulation and evaluation of caffeine chewing gum.咖啡因口香糖的设计、配方与评估
Adv Biomed Res. 2013 Jul 30;2:72. doi: 10.4103/2277-9175.115806. eCollection 2013.
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Design, formulation and evaluation of nicotine chewing gum.尼古丁口香糖的设计、配方与评估
Adv Biomed Res. 2012;1:57. doi: 10.4103/2277-9175.100175. Epub 2012 Aug 28.
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Effects of chewing gum on the stress and work of university students.咀嚼口香糖对大学生压力和工作的影响。
Appetite. 2012 Jun;58(3):1037-40. doi: 10.1016/j.appet.2012.02.054. Epub 2012 Mar 5.
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Medicated chewing gum--a potential drug delivery system.含药咀嚼胶——一种有潜力的药物传递系统。
Expert Opin Drug Deliv. 2010 Jul;7(7):871-85. doi: 10.1517/17425247.2010.493554.

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