Omengue Andrea Ma, Sobngwi Eugène, Dehayem Mesmin, Balt Eric V, Boli Anne Mo, Choukem Simeon P, Gautier Jean F, Mbanya Jean-Claude
National Obesity Centre, Yaoundé Central Hospital, Yaoundé, Cameroon.
Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Eur Endocrinol. 2018 Apr;14(1):44-46. doi: 10.17925/EE.2018.14.1.44. Epub 2018 Apr 18.
The reliability of capillary blood glucose measurements is tremendously important for patients' care and follow-up. Some factors independent of glucose control could however affect readings during ambulatory monitoring of capillary glucose levels in patients with diabetes mellitus. We sought to evaluate the impact of three body lotions commonly used in Cameroon on different strata of glycaemia. We explored their influence over time on measured capillary glucose values. We enrolled 16 participants. Eligible individuals were adult patients with diabetes (n=12) stratified into three levels of capillary glucose values (100 ± 40 mg/dL [5.55 ± 2.22 mmol/L], 200 ± 40 mg/dL [11.1 ± 2.22 mmol/L] and 300 ± 40 mg/dL [16.65 ± 2.22 mmol/L]) and normoglycaemic individuals (n=4). We measured capillary blood glucose before application, immediately after, then 5, 30 and 60 minutes after application of sweet almond oil, corticosteroid cream and hydroquinone lotion. The measurements made on impregnated body lotion-permeated fingers were compared to that of a clean finger. We observed a significant increase (delta [95% confidence interval, CI]: 119.5% [77.4-222.1]) of capillary glucose level immediately after administration of hydroquinone-containing body lotion (p<0.001). Capillary glucose values after the use of corticoid cream and sweet almond oil was stable 5, 30 and 60 minutes after application (p=0.875 and p=0.883 respectively). In the case of the hydroquinone-containing body lotion, there was a significant difference between capillary glucose level at 5 minutes (delta [95%CI]: 81.6% [55.3-214.2]; p<0.001), 30 minutes (delta [95%CI]: 71.6% [21.8-134.6]; p<0.001) and 60 minutes (delta [95%CI]: 58.3% [2.8-133.3]; p=0.013) after application compared to the value obtained from the clean finger. We observed from our study that there were significant variations in capillary blood glucose measurements induced by the use of hydroquinone lotion.
毛细血管血糖测量的可靠性对于患者的护理和随访极为重要。然而，一些与血糖控制无关的因素可能会影响糖尿病患者动态监测毛细血管血糖水平时的读数。我们试图评估喀麦隆常用的三种身体乳液对不同血糖分层的影响。我们探究了它们随时间对测量的毛细血管血糖值的影响。我们招募了16名参与者。符合条件的个体为成年糖尿病患者（n = 12），分为三个毛细血管血糖值水平（100±40mg/dL [5.55±2.22mmol/L]、200±40mg/dL [11.1±2.22mmol/L] 和300±40mg/dL [16.65±2.22mmol/L]）以及血糖正常的个体（n = 4）。我们在涂抹甜杏仁油、皮质类固醇乳膏和对苯二酚乳液之前、之后立即以及之后5、30和60分钟测量毛细血管血糖。将在涂抹了身体乳液的手指上进行的测量结果与干净手指的测量结果进行比较。我们观察到，在涂抹含对苯二酚的身体乳液后，毛细血管血糖水平立即显著升高（差值[95%置信区间，CI]：119.5% [77.4 - 222.1]）（p<0.001）。使用皮质类固醇乳膏和甜杏仁油后，5、30和60分钟后的毛细血管血糖值保持稳定（分别为p = 0.875和p = 0.883）。对于含对苯二酚的身体乳液，与干净手指获得的值相比，涂抹后5分钟（差值[95%CI]：81.6% [55.3 - 214.2]；p<0.001）、30分钟（差值[95%CI]：71.6% [21.8 - 134.6]；p<0.001）和60分钟（差值[95%CI]：58.3% [2.8 - 133.3]；p = 0.013）时的毛细血管血糖水平存在显著差异。我们从研究中观察到，使用对苯二酚乳液会导致毛细血管血糖测量值出现显著变化。
