Sanders Rebecca, Bustin Stephen, Huggett Jim, Mason Deborah
Molecular and Cell Biology, Science and Innovation, LGC, Queens Road, Teddington, Middlesex TW11 0LY, UK.
Faculty of Medical Science, Anglia Ruskin University, Michael Salmon Building, Chelmsford, Essex CM1 1SQ, UK.
Biomol Detect Quantif. 2018 Mar 16;15:13-17. doi: 10.1016/j.bdq.2018.03.001. eCollection 2018 May.
Human health and safety depend on reliable measurements in medical diagnosis and on tests that support the selection and evaluation of therapeutic intervention and newly discovered molecular biomarkers must pass a rigorous evaluation process if they are to be of benefit to patients. Measurement standardization helps to maximize data quality and confidence and ultimately improves the reproducibility of published research. Failure to consider how a given experiment may be standardized can be costly, both financially as well as in time and failure to perform and report pre-clinical research in an appropriately rigorous manner will hinder the development of diagnostic methods. Hence standardization is a crucial step in maintaining the integrity of scientific studies and is a key feature of robust investigation.
人类健康与安全取决于医学诊断中的可靠测量以及支持治疗干预选择和评估的测试，并且新发现的分子生物标志物若要造福患者，必须经过严格的评估过程。测量标准化有助于最大限度地提高数据质量和可信度，并最终提高已发表研究的可重复性。不考虑给定实验如何进行标准化可能会付出高昂代价，无论是在经济方面，还是在时间方面，而且未能以适当严谨的方式开展和报告临床前研究将阻碍诊断方法的发展。因此，标准化是维护科学研究完整性的关键步骤，也是有力调查的关键特征。
