Hollmann Axel, Martinez Melina, Maturana Patricia, Semorile Liliana C, Maffia Paulo C
Laboratory of Molecular Microbiology, Institute of Basic and Applied Microbiology, National University of Quilmes, Bernal, Argentina.
Centro de Investigación en Biofísica Aplicada y Alimentos, Consejo Nacional de Investigaciones Científicas y Técnicas and National University of Santiago del Estero, Santiago del Estero, Argentina.
Front Chem. 2018 Jun 5;6:204. doi: 10.3389/fchem.2018.00204. eCollection 2018.
Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown antimicrobial activity against a wide range of bacterial species, including multiresistant bacteria; however, toxicity is the major barrier to convert antimicrobial peptides into active drugs. A profound and proper understanding of the complex interactions between these peptides and biological membranes using biophysical tools and model membranes seems to be a key factor in the race to develop a suitable antimicrobial peptide therapy for clinical use. In the search for such therapy, different combined approaches with conventional antibiotics have been evaluated in recent years and demonstrated to improve the therapeutic potential of AMPs. Some of these approaches have revealed promising additive or synergistic activity between AMPs and chemical antibiotics. This review will give an insight into the possibilities that physicochemical tools can give in the AMPs research and also address the state of the art on the current promising combined therapies between AMPs and conventional antibiotics, which appear to be a plausible future opportunity for AMPs treatment.
抗菌肽是很有前景的新型抗生素，因为它们已显示出对多种细菌具有抗菌活性，包括多重耐药菌；然而，毒性是将抗菌肽转化为活性药物的主要障碍。使用生物物理工具和模型膜深入且恰当地理解这些肽与生物膜之间的复杂相互作用，似乎是开发适用于临床的抗菌肽疗法竞赛中的关键因素。在寻找此类疗法的过程中，近年来已评估了与传统抗生素的不同联合方法，并证明这些方法可提高抗菌肽的治疗潜力。其中一些方法已揭示出抗菌肽与化学抗生素之间有前景的相加或协同活性。本综述将深入探讨物理化学工具在抗菌肽研究中所能提供的可能性，还将阐述抗菌肽与传统抗生素之间当前有前景的联合疗法的现状，这似乎是抗菌肽治疗未来一个可行的机会。
