抗菌肽鲎素I与顺铂联合应用抗肿瘤作用的体外研究
In Vitro Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin.
作者信息
Kuzmin D V, Emel'yanova A A, Kalashnikova M B, Panteleev P V, Ovchinnikova T V
机构信息
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2018 Jun;165(2):220-224. doi: 10.1007/s10517-018-4134-6. Epub 2018 Jun 19.
We studied combined effect of β-hairpin antimicrobial peptide tachyplesin I and cytotoxic agent cisplatin on tumor and normal human cell lines. MTT assay and flow cytometry showed that tachyplesin I selectively sensitized cancer cells to cisplatin in specified concentration ratios. In vitro experiments demonstrated that combined use of tachyplesin I and cisplatin allows decreasing the effective dose of the cytostatic thus reducing nonspecific toxicity.
我们研究了β-发夹抗菌肽鲎素I和细胞毒性药物顺铂对肿瘤细胞系和正常人细胞系的联合作用。MTT法和流式细胞术表明，鲎素I在特定浓度比下能选择性地使癌细胞对顺铂敏感。体外实验表明，联合使用鲎素I和顺铂可降低细胞抑制剂的有效剂量，从而降低非特异性毒性。
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