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原发性干燥综合征患者唇腺淋巴细胞的免疫表型及临床特征

Immunophenotypes and clinical features of lymphocytes in the labial gland of primary Sjogren's syndrome patients.

作者信息

Sun Wenwen, Zhang Na, Zhang Yujie, Shao Zonghong, Gong Lu, Wei Wei

机构信息

Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin, China.

Department of Pathology, Tianjin Medical University General Hospital, Tianjin, China.

出版信息

J Clin Lab Anal. 2018 Nov;32(9):e22585. doi: 10.1002/jcla.22585. Epub 2018 Jun 19.

DOI:10.1002/jcla.22585
PMID:29923220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6282844/
Abstract

OBJECTIVE

To investigate consistency of lymphocyte immunophenotype between labial gland and peripheral blood in patients with primary Sjogren's syndrome (pSS).

METHODS

Seventy-one pSS patients and 35 patients with maxillofacial trauma were included in the study. Based on the ratio of CD20 to CD3 in labial gland from 71 pSS patients, they were divided into the high and (n = 48) and low CD20 expression group (n = 23). Lymphocyte immunophenotypes in labial glands, course of disease, erythrocyte sedimentation rate (ESR), C-reactive protein, immunoglobulin, and complement levels were analyzed.

RESULTS

In the labial gland, the levels of IgG, IgA, IgM, and C3c were higher, but C1q was lower in the pSS group than in the control group (all P < .05). CD20 was detected in labial gland samples of all pSS patients, in which CD3 was positive in 66 (93.0%) patients, and negative in 5 (7.0%). The plasma levels of IgG, IgA, IgM, and CRP, and ESR were higher, but serum C4 level was lower in pSS patients than in the control group (all P < .01). Serum IgG level, ESR, and labial gland CD20 were higher in the high CD20 expression group than the low expression group (all P < .05).

CONCLUSION

Primary Sjogren's syndrome patients had a higher expression of CD20 positive infiltrating lymphocytes of the labial gland, accompanied with the changes of immunoglobulins, and complements in both the labial gland and peripheral blood.

摘要

目的

探讨原发性干燥综合征（pSS）患者唇腺与外周血淋巴细胞免疫表型的一致性。

方法

本研究纳入71例pSS患者和35例颌面外伤患者。根据71例pSS患者唇腺中CD20与CD3的比例，将其分为高CD20表达组（n = 48）和低CD20表达组（n = 23）。分析唇腺中的淋巴细胞免疫表型、病程、红细胞沉降率（ESR）、C反应蛋白、免疫球蛋白和补体水平。

结果

在唇腺中，pSS组的IgG、IgA、IgM和C3c水平高于对照组，但C1q低于对照组（均P <.05）。所有pSS患者的唇腺样本中均检测到CD20，其中66例（93.0%）患者CD3呈阳性，5例（7.0%）呈阴性。pSS患者的血浆IgG、IgA、IgM和CRP水平以及ESR高于对照组，但血清C4水平低于对照组（均P <.01）。高CD20表达组的血清IgG水平、ESR和唇腺CD20高于低表达组（均P <.05）。

结论

原发性干燥综合征患者唇腺中CD20阳性浸润淋巴细胞表达较高，同时伴有唇腺和外周血中免疫球蛋白及补体的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/29376d5c0559/JCLA-32-e22585-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/c9c2202278bb/JCLA-32-e22585-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/d2b323b706ed/JCLA-32-e22585-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/73b00c554d85/JCLA-32-e22585-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/af9671f6d6dd/JCLA-32-e22585-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/29376d5c0559/JCLA-32-e22585-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/c9c2202278bb/JCLA-32-e22585-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/d2b323b706ed/JCLA-32-e22585-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/73b00c554d85/JCLA-32-e22585-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/af9671f6d6dd/JCLA-32-e22585-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ed/6817061/29376d5c0559/JCLA-32-e22585-g005.jpg

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