Tamiolakis P, Theofilou V-I, Tosios K-I, Sklavounou-Andrikopoulou A
Department of Oral Medicine and Oral Pathology, School of Dentistry, National and Kapodistrian University of Athens, Greece, 2 Thivon Str, 11527, Goudi, Athens, Greece,
Med Oral Patol Oral Cir Bucal. 2018 Jul 1;23(4):e429-e435. doi: 10.4317/medoral.22342.
Oral verruciform xanthoma (OVX) is a rare lesion. The purpose of the present study is to describe the clinical features of 13 OVXs and review all cases reported in the English literature.
Thirteen cases of OVX diagnosed during a 47-year period were retrospectively collected. The patients gender and age, as well as the main clinical features of the lesions were retrieved from the biopsy request forms. Pubmed, Scopus and Google ScholarTM electronic databases were searched with the key word verruciform xanthoma. Only cases of histologically confirmed OVX were included in the study.
The 13 OVXs represented approximately 0.04% of 35,617 biopsies accessioned during the study period. They affected 13 patients, 8 males and 5 females with a mean age of 48.8±14 years. They mainly appeared as asymptomatic granular nodules or plaques, with elastic or normal consistency and white color, in the gingiva or hard palate. Literature review yielded 416 cases of OVX. With the addition of cases of the present study, 429 cases of OVX have been presented in the English literature. OVX has a slight male predominance with a male to female ratio of 1.4:1 and the majority of patients are in the 5th to 7th decade of life. Clinically, OVX mainly presents as an asymptomatic, single, papillary or granular plaque or nodule, with elastic or soft consistency and white, red or pink color. It measures approximately 1cm and is most commonly located on the gingiva, tongue, hard palate or buccal mucosa. The treatment of choice is surgical excision with little rates of recurrence.
Verruciform xanthoma is a rare lesion most often encountered on the ginigival mucosa. As its clinical presentation is not pathognomonic, it should be included in the differential diagnosis of verrucous or papillary lesions.
口腔疣状黄瘤（OVX）是一种罕见病变。本研究旨在描述13例OVX的临床特征，并回顾英文文献中报道的所有病例。
回顾性收集47年间诊断的13例OVX病例。从活检申请表中获取患者的性别、年龄以及病变的主要临床特征。使用关键词“疣状黄瘤”搜索PubMed、Scopus和谷歌学术电子数据库。本研究仅纳入组织学确诊的OVX病例。
13例OVX约占研究期间35617例活检病例的0.04%。它们累及13名患者，8名男性和5名女性，平均年龄为48.8±14岁。它们主要表现为牙龈或硬腭处无症状的颗粒状结节或斑块，质地有弹性或正常，颜色为白色。文献回顾得出416例OVX病例。加上本研究的病例，英文文献中共报道了429例OVX。OVX男性略占优势，男女比例为1.4:1，大多数患者年龄在50至70岁之间。临床上，OVX主要表现为无症状的单个乳头状或颗粒状斑块或结节，质地有弹性或柔软，颜色为白色、红色或粉红色。大小约为1厘米，最常见于牙龈、舌头、硬腭或颊黏膜。首选治疗方法是手术切除，复发率较低。
疣状黄瘤是一种罕见病变，最常出现在牙龈黏膜。由于其临床表现不具有特异性，应将其纳入疣状或乳头状病变的鉴别诊断中。
