口腔扁平苔藓和生殖器扁平苔藓中p16表达均增加。
Increased expression of p16 in both oral and genital lichen planus.
作者信息
Danielsson K, Olah J, Zohori-Zangeneh R, Nylander E, Ebrahimi M
机构信息
Department of Odontology, Umeå University, SE - 901 85 Umeå, Sweden,
出版信息
Med Oral Patol Oral Cir Bucal. 2018 Jul 1;23(4):e449-e453. doi: 10.4317/medoral.22432.
BACKGROUND
Lichen Planus, LP, is an inflammatory disease of possible autoimmune origin affecting mainly oral and genital mucosa and skin. According to the WHO oral LP is considered a potentially malignant disorders. The p16 tumour suppressor protein can act as an inhibitor of cyclin dependent kinases 4 and 6 and thus down regulate cell cycle progression. Since the discovery of p16 several studies have evaluated its expression in various forms of human cancers. The aim of this study was to evaluate and compare the expression of p16 in oral and genital LP and corresponding healthy mucosa.
MATERIAL AND METHODS
A total of 76 cases of oral LP (OLP), 34 cases of genital LP (GLP), 12 cases of healthy oral and 9 cases of healthy genital mucosa were analysed by the use of immunohistochemistry.
RESULTS
Data showed p16 to be highly expressed in both oral and genital LP, higher than in oral (p=0.000), and genital controls (p=0.002).
CONCLUSIONS
Results suggest that the over-expression of p16 seen in LP play a part in the histopathology of the disease.
背景
扁平苔藓（LP）是一种可能起源于自身免疫的炎症性疾病，主要影响口腔和生殖器黏膜以及皮肤。根据世界卫生组织的分类，口腔扁平苔藓被认为是一种潜在的恶性疾病。p16肿瘤抑制蛋白可作为细胞周期蛋白依赖性激酶4和6的抑制剂，从而下调细胞周期进程。自p16被发现以来，多项研究评估了其在各种人类癌症中的表达情况。本研究的目的是评估和比较p16在口腔和生殖器扁平苔藓以及相应健康黏膜中的表达。
材料与方法
通过免疫组织化学分析了76例口腔扁平苔藓（OLP）、34例生殖器扁平苔藓（GLP）、12例健康口腔黏膜和9例健康生殖器黏膜。
结果
数据显示p16在口腔和生殖器扁平苔藓中均高度表达，高于口腔对照组（p = 0.000）和生殖器对照组（p = 0.002）。
结论
结果表明，在扁平苔藓中观察到的p16过表达在该疾病的组织病理学中起作用。
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