Zhou Wei, Fang Fang, Zhu Wenting, Chen Zi-Jiang, Du Yanzhi, Zhang Jun
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China.
Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong 250100, China.
Int J Environ Res Public Health. 2016 Dec 27;14(1):18. doi: 10.3390/ijerph14010018.
To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) and inhibin B (INHB) in 268 infertile women diagnosed with PCOS. BPA was detected in all women with a median concentration of 2.35 ng/mL (the 25th and 75th percentiles of 1.47 ng/mL and 3.95 ng/mL). A unit increase in BPA_Cre was associated with a significant decrease of 0.34 in AFC (β = -0.34, 95% CI = -0.60, -0.08; = 0.01). Likewise, BPA was negatively associated with AMH and day-3 FSH levels, but neither of them reached statistical significance. No association was observed between BPA and INHB. Our results suggest that in women with PCOS, BPA may affect ovarian follicles and, therefore, reduce ovarian reserve.
为了更好地了解双酚A（BPA）暴露对多囊卵巢综合征（PCOS）女性卵巢储备的可能影响，我们测量了肌酐校正后的尿BPA（BPA_Cre）浓度，并使用回归模型评估了268例诊断为PCOS的不孕女性尿BPA水平与窦卵泡计数（AFC）、抗苗勒管激素（AMH）、第3天卵泡刺激素水平（FSH）和抑制素B（INHB）之间的关联。所有女性均检测到BPA，中位数浓度为2.35 ng/mL（第25和第75百分位数分别为1.47 ng/mL和3.95 ng/mL）。BPA_Cre每增加一个单位，AFC显著降低0.34（β = -0.34，95% CI = -0.60，-0.08；P = 0.01）。同样，BPA与AMH和第3天FSH水平呈负相关，但均未达到统计学显著性。未观察到BPA与INHB之间存在关联。我们的结果表明，在PCOS女性中，BPA可能影响卵巢卵泡，从而降低卵巢储备。
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