Badawy Ahmed A, Kasem Samaa A, Rashwan Doaa, Al Menesy Tarek, Adel Ghada, Mokhtar Ali M, Badawy Yasmin A
Anesthesia department, Faculty of medicine, Cairo University, Giza, Egypt.
Anesthesia department, Faculty of medicine, Beni Suef University, Beni Suef, Egypt.
BMC Anesthesiol. 2018 Jun 20;18(1):73. doi: 10.1186/s12871-018-0533-5.
Short acting inhalational anesthetic (Desflurane) produces emergence agitation (EA) in pediatrics with an incidence up to 80%. The aim of the present study was to examine the role of Gabapentin oral solution in attenuating desflurane associated EA in children after strabismus surgery under general anesthesia.
Seventy patients, 2-6 years old, scheduled for strabismus surgery were randomly allocated into two groups (35 each); Control group (c): received 5 ml of oral strawberry juice (placebo) and Gabapentin group (G) received 5 mg/Kg gabapentin oral solution in 5 ml strawberry juice, 1 h before anesthesia. Patient separation, cooperation, emergence incidence and emergence severity were assessed. Also time to extubation and time to emergence, duration of PACU stay, PONV and number of patients required meperidine postoperatively were recorded.
Duration to extubation and duration to emergence were statistically prolonged in gabapentin group compared to the control group. The incidence of EA and its severity were reduced in gabapentin group with more tendencies to be asleep and less attentive. More patients in the control group required postoperative meperidine to reduce crying and agitation.
Oral gabapentin 5 mg/kg reduced the incidence and severity scoring of emergence agitation (by 20%) with more tendencies for sleeping with preserved response to stimuli in PACU.
Number: NCT03347916 , date: November 17, 2017, retrospectively.
短效吸入麻醉剂（地氟烷）在儿科患者中会引发苏醒期躁动（EA），发生率高达80%。本研究的目的是探讨加巴喷丁口服溶液在全身麻醉下斜视手术后减轻儿童地氟烷相关EA中的作用。
70例年龄在2至6岁、计划进行斜视手术的患者被随机分为两组（每组35例）；对照组（c）：在麻醉前1小时接受5毫升草莓味口服果汁（安慰剂），加巴喷丁组（G）在5毫升草莓味果汁中接受5毫克/千克加巴喷丁口服溶液。评估患者的分离情况、合作程度、苏醒发生率和苏醒严重程度。还记录了拔管时间、苏醒时间、麻醉后监护病房（PACU）停留时间、术后恶心呕吐（PONV）情况以及术后需要哌替啶的患者数量。
与对照组相比，加巴喷丁组的拔管时间和苏醒时间在统计学上延长。加巴喷丁组的EA发生率及其严重程度降低，入睡倾向增加，注意力降低。对照组更多患者术后需要哌替啶来减少哭闹和躁动。
口服5毫克/千克加巴喷丁可降低苏醒期躁动的发生率和严重程度评分（降低20%），在PACU中入睡倾向增加，对刺激的反应保留。
编号：NCT03347916，日期：2017年11月17日，回顾性注册。
