Harland Jane, Furuta Michiko, Takeuchi Kenji, Tanaka Shunichi, Yamashita Yoshihisa
Department of Dental Education, Kyushu University Faculty of Dental Science.
Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science.
J Oral Sci. 2018;60(2):226-231. doi: 10.2334/josnusd.17-0225.
Periodontitis was reported to be associated with chronic obstructive pulmonary disease (COPD), and both diseases are related to smoking. To identify associations between periodontitis, smoking, and COPD, this cross-sectional study enrolled 1474 Japanese men (mean age 55.2 ± 8.9 years) surveyed between 2003 and 2006. Periodontal status was evaluated by using the community periodontal index. Periodontitis was defined as the presence of at least one sextant with a pocket depth ≥4 mm. Lung function was measured by spirometry, and COPD was defined as ratio of forced expiratory volume after 1 second to forced vital capacity of <0.70. Logistic regression analysis showed that the association between COPD and smoking was stronger for men with periodontitis (odds ratio 2.45; 95% confidence interval 1.37-4.37) than for those without periodontitis (odds ratio 1.64; 95% confidence interval 0.91-2.94), after adjusting for age, number of present teeth, body mass index, alcohol intake, occupation, hypertension, and diabetes. The association between smoking and COPD was significant for men with periodontitis but was weaker for those without periodontitis. These findings suggest that periodontitis modifies the association between smoking and COPD.
据报道，牙周炎与慢性阻塞性肺疾病（COPD）有关，且这两种疾病都与吸烟有关。为了确定牙周炎、吸烟与COPD之间的关联，这项横断面研究纳入了2003年至2006年期间接受调查的1474名日本男性（平均年龄55.2±8.9岁）。使用社区牙周指数评估牙周状况。牙周炎的定义为至少有一个牙 sextant 的牙周袋深度≥4mm。通过肺活量测定法测量肺功能，COPD 的定义为第1秒用力呼气量与用力肺活量之比<0.70。逻辑回归分析显示，在调整年龄、现存牙齿数量、体重指数、酒精摄入量、职业、高血压和糖尿病后，患有牙周炎的男性中COPD与吸烟之间的关联（优势比2.45；95%置信区间1.37 - 4.37）比未患牙周炎的男性更强（优势比1.64；95%置信区间0.91 - 2.94）。吸烟与COPD之间的关联在患有牙周炎的男性中显著，但在未患牙周炎的男性中较弱。这些发现表明，牙周炎改变了吸烟与COPD之间的关联。
