Hammond M E, Sause W T
Cancer. 1985 Oct 1;56(7):1624-9. doi: 10.1002/1097-0142(19851001)56:7<1624::aid-cncr2820560727>3.0.co;2-3.
Twenty-five cases of neuroendocrine tumors of lung, including bronchial carcinoids (eight), malignant (atypical) carcinoids (nine), and large cell undifferentiated carcinomas (LCAC) with neuroendocrine differentiation (eight) were analyzed. All carcinoids (BC) could be diagnosed by light microscopy; all patients with these tumors are alive without disease. Five of nine malignant carcinoids (MC) could be recognized histologically; four of nine were called LCAC and required electron microscopy for diagnosis. Survival correlated best with stage of diagnosis. High-grade neuroendocrine carcinomas (LCAC-NE) required electron microscopy for their diagnosis. Seven were LCAC histologically; one was diagnosed as malignant carcinoid (MC). Such tumors resemble small cell anaplastic carcinomas ultrastructurally and behaviorally. All eight patients with such high-grade tumors died of their disease; three of eight had no nodal metastases at the time of resection. This experience suggests it is clinically important to distinguish neuroendocrine neoplasms since behavior is predictable on the basis of morphology.
对25例肺神经内分泌肿瘤进行了分析，其中包括支气管类癌（8例）、恶性（非典型）类癌（9例）以及具有神经内分泌分化的大细胞未分化癌（LCAC，8例）。所有类癌（BC）均可通过光学显微镜诊断；所有患有这些肿瘤的患者均存活且无疾病。9例恶性类癌（MC）中有5例可通过组织学识别；9例中有4例被称为LCAC，需要电子显微镜进行诊断。生存率与诊断阶段相关性最佳。高级别神经内分泌癌（LCAC-NE）需要电子显微镜进行诊断。组织学上有7例为LCAC；1例被诊断为恶性类癌（MC）。此类肿瘤在超微结构和行为上类似于小细胞间变性癌。所有8例患有此类高级别肿瘤的患者均死于其疾病；8例中有3例在切除时无淋巴结转移。该经验表明，区分神经内分泌肿瘤在临床上很重要，因为其行为可根据形态学进行预测。
