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活性氧物种触发的可调硫化氢释放。

Reactive Oxygen Species-Triggered Tunable Hydrogen Sulfide Release.

机构信息

Department of Chemistry , Indian Institute of Science Education and Research Pune , Dr. Homi Bhabha Road , Pashan Pune 411 008 , Maharashtra , India.

出版信息

Org Lett. 2018 Jul 6;20(13):3766-3770. doi: 10.1021/acs.orglett.8b01356. Epub 2018 Jun 21.

DOI:10.1021/acs.orglett.8b01356
PMID:29927612
Abstract

A series of carbamothioates with tunable release of HS after activation by reactive oxygen species are reported. The half-lives of HS release could be tuned from 24 to 203 min by varying the basicity of the amine.

摘要

报道了一系列经活性氧物种激活后可释放 HS 的可调节的碳酰胺硫醇。通过改变胺的碱性,可以将 HS 释放的半衰期从 24 分钟调节到 203 分钟。

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