Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, P.O.BOX: 196, Gondar, Ethiopia.
Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
BMC Infect Dis. 2018 Jun 22;18(1):283. doi: 10.1186/s12879-018-3189-3.
The burden of mother-to-child transmission rate of HIV is high and risk factors are common in Ethiopia. This systematic review and meta-analysis intended to provide the pooled estimation of mother-to-child transmission rate and its risk factors in Ethiopia.
We searched PubMed, Google Scholar, EMBASE and Web of Science electronic databases for all available references. We included observational studies including case-control, cohort, and cross-sectional studies. The search was further limited to studies conducted in Ethiopia and publish in English. Heterogeneity was checked using the I statistic. Egger's test and the funnel plot were used to assess publication bias. A meta-analysis using a weighted inverse variance random-effects model was performed.
A total of 18 studies with 6253 individuals were included in this systematic review and meta-analysis. Of these, 14 studies with 4624 individuals were used to estimate the prevalence. The estimated pooled prevalence of mother-to-child transmission of HIV was 11.4% (95% CI = 9.1-13.7). The pooled adjusted odds ratio (AOR) of mother-to-child transmission of HIV for the infants from rural area was 3.8 (95% CI = 1.4 to 6.3), infants delivered at home was 3.2 (95% CI = 1.2 to 5.2), infant didn't take antiretroviral prophylaxis was 5.8 (95% CI = 1.5 to 10.3), mother didn't take antiretroviral prophylaxis was 6.1 (95% CI = 2.5 to 9.6), mothers didn't receive PMTCT intervention was 5.1 (95% CI = 1.6, 8.6), and on mixed feeding was 4.3 (95% CI = 1.8 to 6.7).
This systematic review and meta-analysis showed that mother-to-child transmission rate of HIV was high in Ethiopia. Being from the rural residence, home delivery, not taking antiretroviral prophylaxis, the absence of PMTCT intervention, and mixed infant feeding practices increased the risk of HIV transmission.
It is registered in the Prospero database: (PROSPERO 2017: CRD42017078232 ).
在埃塞俄比亚，艾滋病毒母婴传播率负担高，且风险因素普遍存在。本系统评价和荟萃分析旨在提供埃塞俄比亚母婴传播率及其危险因素的汇总估计。
我们检索了 PubMed、Google Scholar、EMBASE 和 Web of Science 电子数据库，以获取所有可用的参考文献。我们纳入了观察性研究，包括病例对照、队列和横断面研究。搜索范围进一步限于在埃塞俄比亚进行的并以英文发表的研究。使用 I ² 统计量检查异质性。Egger 检验和漏斗图用于评估发表偏倚。使用加权倒数方差随机效应模型进行荟萃分析。
这项系统评价和荟萃分析共纳入了 18 项研究，涉及 6253 人。其中，14 项研究（涉及 4624 人）用于估计患病率。艾滋病毒母婴传播的估计合并患病率为 11.4%（95%CI=9.1-13.7）。来自农村地区的婴儿、在家分娩的婴儿、未接受抗逆转录病毒预防的婴儿、未接受抗逆转录病毒预防的母亲、未接受 PMTCT 干预的母亲以及混合喂养的婴儿的 HIV 母婴传播的合并调整比值比（AOR）分别为 3.8（95%CI=1.4-6.3）、3.2（95%CI=1.2-5.2）、5.8（95%CI=1.5-10.3）、6.1（95%CI=2.5-9.6）、5.1（95%CI=1.6-8.6）和 4.3（95%CI=1.8-6.7）。
本系统评价和荟萃分析显示，埃塞俄比亚的艾滋病毒母婴传播率较高。来自农村地区、在家分娩、未接受抗逆转录病毒预防、未接受 PMTCT 干预以及混合婴儿喂养方式均增加了 HIV 传播的风险。
它在 Prospero 数据库中注册：（PROSPERO 2017：CRD42017078232）。
