Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2018 May 17;33(26):e179. doi: 10.3346/jkms.2018.33.e179. eCollection 2018 Jun 25.
The aim of the study was to examine the characteristics of alpha wave peak frequency, power, and coherence in patients with schizophrenia.
Thirty-one patients with schizophrenia and age- and sex-matched subjects with no psychopathology were enrolled. All study participants underwent quantitative electroencephalography (QEEG). Alpha-related values, including peak frequency, power, and coherence, were evaluated.
Alpha peak frequency on the Oz area was slower in the schizophrenia group than that in the control group. However, no differences in absolute or relative power were observed between the two groups. Significant reductions in absolute and relative coherence were observed at the C3-C4 and T3-T4 nodes in the patients with schizophrenia. Relative coherence was reduced at the P3-P4 nodes.
This study focused on alpha variables detected in QEEG as intrinsic values to distinguish schizophrenia from a healthy control. The results suggest decreased alpha peak frequency of the occipital lobe and decreased coherence between the two hemispheres in patients with schizophrenia. A further study could elucidate the causal relationship and biological meaning of the variations in alpha waves in patients with schizophrenia.
本研究旨在探讨精神分裂症患者的阿尔法波峰频率、功率和相干性的特征。
纳入 31 名精神分裂症患者和年龄、性别匹配的无精神病理学对照者。所有研究参与者均接受定量脑电图（QEEG）检查。评估了与阿尔法相关的数值，包括峰频率、功率和相干性。
精神分裂症组 Oz 区的阿尔法波峰频率较对照组慢。然而，两组之间的绝对和相对功率没有差异。在患者的 C3-C4 和 T3-T4 节点处，绝对和相对相干性显著降低。在 P3-P4 节点处，相对相干性降低。
本研究重点关注 QEEG 检测到的作为区分精神分裂症与健康对照组的内在值的阿尔法变量。结果表明，精神分裂症患者的枕叶阿尔法波峰频率降低，两半球之间的相干性降低。进一步的研究可以阐明精神分裂症患者阿尔法波变化的因果关系和生物学意义。
