脑胶质瘤患者中人类免疫缺陷病毒感染的患病率：该病毒对胶质瘤有保护作用吗？
Prevalence of human immunodeficiency virus infection in brain glioma patients: Is the virus protective from gliomas?
作者信息
Jokonya Luxwell, Musara Aaron, Esene Ignatius Ngene, Kabulo Kantenga Dieu Merci, Kabeya Charles Matumba, Kalangu Kazadi Kaluile Ntenga
机构信息
Department of Surgery, University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe.
Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, USA.
出版信息
Surg Neurol Int. 2018 May 24;9:103. doi: 10.4103/sni.sni_423_17. eCollection 2018.
BACKGROUND
Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is associated with an increased prevalence of some malignancies. However, some observational studies have revealed an ever-decreasing prevalence of HIV in glioma patients. The relationship between HIV and brain gliomas has not been well established.
METHODS
A cross-sectional study was carried out in sub-Sahara Africa, a high HIV prevalence setting, to determine the prevalence of HIV among all glioma patients over a 2-year period.
RESULTS
A markedly reduced prevalence of HIV was found in glioma patients (8.3%) in comparison to the general population (14.3%). The presumably "antiglioma effect" of HIV and/or its treatment resulted in a 42% decrease in glioma occurrence in HIV positive patients compared to HIV negative individuals. Age and sex-adjusted prevalence were also lower among glioma patients with the protective effect observed more in younger patients and female sex.
CONCLUSION
Our results corroborate the protective effect of HIV positivity vis-à -vis gliomas. This "antiglioma effect" could be attributed to either the HIV, its treatment, or both. Future studies focused on this "effect" may help unveil better preventative and possible therapeutic avenues for gliomas.
背景
人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）与某些恶性肿瘤的患病率增加有关。然而，一些观察性研究显示，胶质瘤患者中HIV的患病率在不断下降。HIV与脑胶质瘤之间的关系尚未完全明确。
方法
在撒哈拉以南非洲这个HIV高流行地区开展了一项横断面研究，以确定两年内所有胶质瘤患者中HIV的患病率。
结果
与普通人群（14.3%）相比，胶质瘤患者中HIV的患病率显著降低（8.3%）。HIV及其治疗可能产生的“抗胶质瘤效应”导致HIV阳性患者的胶质瘤发生率比HIV阴性个体降低了42%。胶质瘤患者经年龄和性别调整后的患病率也较低，这种保护作用在年轻患者和女性中更为明显。
结论
我们的结果证实了HIV阳性对胶质瘤具有保护作用。这种“抗胶质瘤效应”可能归因于HIV本身、其治疗方法或两者兼而有之。未来针对这种“效应”的研究可能有助于揭示更好的胶质瘤预防和潜在治疗途径。
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