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原发性胃癌中的c-myc基因扩增

c-myc Gene amplification in primary stomach cancer.

作者信息

Koda T, Matsushima S, Sasaki A, Danjo Y, Kakinuma M

出版信息

Jpn J Cancer Res. 1985 Jul;76(7):551-4.

PMID:2993214
Abstract

Fourteen human primary stomach cancer tissues were screened by Southern blot hybridization using six oncogene probes (myc, myb, H-ras, K-ras, abl, mos), and an amplification of c-myc oncogene was found in one tissue. This is the first report of c-onc amplification in primary stomach cancer tissue.

摘要

使用六种癌基因探针(myc、myb、H-ras、K-ras、abl、mos)通过Southern印迹杂交对14个人原发性胃癌组织进行筛选,发现其中一个组织中c-myc癌基因存在扩增。这是原发性胃癌组织中c-onc扩增的首次报道。

相似文献

1
c-myc Gene amplification in primary stomach cancer.原发性胃癌中的c-myc基因扩增
Jpn J Cancer Res. 1985 Jul;76(7):551-4.
2
C-myc amplification and cluster analysis in human gastric carcinoma.人胃癌中的C-myc基因扩增与聚类分析
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3
[Identification of an abnormally over-expressed gene in human stomach cancer by differential screening].
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Heterogeneous protooncogene amplification correlates with tumor progression and presence of metastases in gastric cancer patients.异质性原癌基因扩增与胃癌患者的肿瘤进展和转移的存在相关。
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Amplification of c-yes-1 proto-oncogene in a primary human gastric cancer.
Jpn J Cancer Res. 1985 Oct;76(10):907-10.
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DNA amplification of the c-myc and c-erbB-1 genes in a human stomach cancer.
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[Correlation between malignancy of gastric cancer and c-myc DNA amplification or overexpression of c-myc protein].[胃癌恶性程度与c-myc DNA扩增或c-myc蛋白过表达的相关性]
Gan To Kagaku Ryoho. 1995 Jun;22 Suppl 2:176-9.
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[A study of amplifications of myc gene (c-myc and N-myc) in human ovarian cancer].[人卵巢癌中myc基因(c-myc和N-myc)扩增的研究]
Nihon Sanka Fujinka Gakkai Zasshi. 1990 Mar;42(3):259-63.
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[Novel transforming genes detected in human stomach cancer cells].[在人类胃癌细胞中检测到的新型转化基因]
Gan To Kagaku Ryoho. 1985 Mar;12(3 Pt 2):641-5.
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Is the presence of distant metastasis associated with c-myc amplification in gastric cancer?胃癌中远处转移的存在与c-myc扩增有关吗?
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引用本文的文献

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Role and value of the tumor microenvironment in the progression and treatment resistance of gastric cancer (Review).肿瘤微环境在胃癌进展和治疗抵抗中的作用和价值(综述)。
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Different patterns of DNA alterations detected by restriction landmark genomic scanning in heterogeneous prostate carcinomas.通过限制性内切酶图谱基因组扫描在异质性前列腺癌中检测到的不同DNA改变模式。
Am J Pathol. 1997 Jan;150(1):305-14.
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Growth regulation of rabbit gastric epithelial cells and protooncogene expression.
兔胃上皮细胞的生长调节与原癌基因表达
Dig Dis Sci. 1994 Jul;39(7):1454-63. doi: 10.1007/BF02088048.
4
Evaluation of p62c-myc in benign and malignant gastric epithelia.p62c-myc在胃良恶性上皮中的评估。
Br J Cancer. 1987 Dec;56(6):785-6. doi: 10.1038/bjc.1987.288.
5
Human cancer and cellular oncogenes.人类癌症与细胞癌基因。
Biochem J. 1987 Apr 15;243(2):313-27. doi: 10.1042/bj2430313.
6
C-myc oncogene product P62c-myc in ovarian mucinous neoplasms: immunohistochemical study correlated with malignancy.C-myc癌基因产物P62c-myc在卵巢黏液性肿瘤中的表达:与恶性肿瘤相关的免疫组织化学研究
J Clin Pathol. 1989 Feb;42(2):148-52. doi: 10.1136/jcp.42.2.148.
7
Co-amplification of c-myc and c-erbB-2 oncogenes in a poorly differentiated human gastric cancer.在低分化人胃癌中c-myc和c-erbB-2癌基因的共扩增
Jpn J Cancer Res. 1989 Oct;80(10):920-3. doi: 10.1111/j.1349-7006.1989.tb01626.x.
8
K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.K-sam是胃癌中的一个扩增基因,属于肝素结合生长因子受体基因家族。
Proc Natl Acad Sci U S A. 1990 Aug;87(15):5983-7. doi: 10.1073/pnas.87.15.5983.
9
Endocervical carcinoma and precursor lesions: c-myc expression and the demonstration of field changes.宫颈管内癌及前驱病变:c-myc 表达与场效应改变的显示
J Clin Pathol. 1991 Nov;44(11):896-9. doi: 10.1136/jcp.44.11.896.